Chromosomal translocation master genes, mouse models and experimental therapeutics

Oncogene
T H Rabbitts

Abstract

Molecular biologists have elucidated general principles about chromosomal translocations by cloning oncogenes or fusion genes at chromosomal translocation junctions. These genes invariably encode intracellular proteins and in acute cancers, often involve transcription and developmental regulators, which are master regulators of cell fate (e.g. LMO2 which is involved in acute leukaemia). Chromosomal translocations are usually associated with specific cell types. The reason for this close association is under investigation using mouse models. We are trying to emulate the cell-specific consequences of chromosomal translocations in mice using homologous recombination in embryonic stem cells to generate de novo chromosomal translocations or to mimic the consequence of these translocations. In addition, chromosomal translocation genes and their products are important targets for therapy. We have designed new therapeutic strategies which include antigen-specific recruitment of endogenous cellular pathways to affect cellular viability and a novel structured form of antisense to ablate the function of fusion mRNAs. We will evaluate these procedures in the mouse models of chromosomal translocations and the long term aim is to perfect rap...Continue Reading

References

Jul 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·C M CroceH Koprowski
Oct 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·M A KennedyT H Rabbitts
Jan 1, 1990·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M JoraschkewitzH Poliwoda
May 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·T BoehmT H Rabbitts
Jan 1, 1991·The Science of the Total Environment·O Pal'usováJ Uhnák
Aug 15, 1987·International Journal of Cancer. Journal International Du Cancer·G KovacsH Baumgärtel
Jan 1, 1970·Zeitschrift für Rechtsmedizin. Journal of legal medicine·R JareckiH Klein
Jan 1, 1984·Canadian Anaesthetists' Society Journal·B J MainP G Jones
Oct 1, 1981·Annals of Human Genetics·M J HobartS Povey
Aug 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·S MalcolmT H Rabbitts
Dec 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·R TaubP Leder
Dec 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·R Dalla-FaveraC M Croce
Jan 1, 1981·Leukemia Research·A BernheimR Barot-Ciorbaru
Aug 1, 1995·Proceedings of the National Academy of Sciences of the United States of America·J Van DeursenG Grosveld
Oct 21, 1994·Cell·K L Schmeichel, M C Beckerle
Nov 10, 1994·Nature·T H Rabbitts
Jun 30, 1994·Nature·R H JacobsonB W Matthews
Jan 1, 1994·Annual Review of Immunology·G WinterH R Hoogenboom
Aug 16, 1994·Proceedings of the National Academy of Sciences of the United States of America·I Sánchez-García, T H Rabbitts
Aug 30, 1994·Proceedings of the National Academy of Sciences of the United States of America·V E Valge-ArcherT H Rabbitts
Jul 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·Q MaA M Buchberg
Jan 1, 1993·Revue française de transfusion et d'hémobiologie : bulletin de la Société nationale de transfusion sanguine·H R HoogenboomG Winter
Jan 1, 1997·Molecular Medicine Today·R W Wagner, W M Flanagan
May 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·R A MacCorkleD M Spencer
May 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·Y YamadaT H Rabbitts
May 2, 1998·Science·A Fischer, B Malissen
Apr 30, 1998·The Journal of Hospital Infection·P G Flanagan
Jul 7, 1998·Journal of Molecular Biology·P MartineauG Winter

❮ Previous
Next ❯

Citations

Jul 25, 2003·Brain Research. Molecular Brain Research·Dung VuArmand Savioz
Jul 2, 2003·Nature Reviews. Cancer·Donald B KohnJoseph C Glorioso
Dec 21, 2007·Leukemia·D Caudell, P D Aplan
Oct 10, 2006·Oncogene·G A Calin, C M Croce
Jun 11, 2004·The New England Journal of Medicine·Alain FischerMarina Cavazzana-Calvo
Feb 18, 2003·Molecular and Cellular Biology·Joanna A Miller, Jonathan Widom
Aug 3, 2007·The Journal of Clinical Investigation·George A Calin, Carlo M Croce
Nov 6, 2009·PLoS Computational Biology·Hedi HegyiPeter Tompa
Aug 18, 2005·International Journal of Hematology·Mariko EguchiMel Greaves
Jul 3, 2003·Médecine sciences : M/S·Sylvie Gisselbrecht
Aug 12, 2009·Seminars in Oncology·Paola ColliniXavier Garcia del Muro
May 21, 2009·Genes, Chromosomes & Cancer·Katrina VanuraBertrand Nadel
Nov 1, 2005·Trends in Genetics : TIG·Peter D Aplan
Apr 14, 2005·Seminars in Cancer Biology·A Daser, T H Rabbitts
Jul 30, 2003·Heredity·F Rousset
Nov 25, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Javier G BlancoMary V Relling

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antisense Oligonucleotides: ND

This feed focuses on antisense oligonucleotide therapies such as Inotersen, Nusinursen, and Patisiran, in neurodegenerative diseases including amyotrophic lateral sclerosis.