Chromosomally Encoded mcr-5 in Colistin-Nonsusceptible Pseudomonas aeruginosa

Antimicrobial Agents and Chemotherapy
Erik SnesrudPatrick McGann

Abstract

Whole-genome sequencing (WGS) of historical Pseudomonas aeruginosa clinical isolates identified a chromosomal copy of mcr-5 within a Tn3-like transposon in P. aeruginosa MRSN 12280. The isolate was nonsusceptible to colistin by broth microdilution, and genome analysis revealed no mutations known to confer colistin resistance. To the best of our knowledge, this is the first report of mcr in colistin-nonsusceptible P. aeruginosa.

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Citations

Feb 21, 2019·Expert Opinion on Pharmacotherapy·Daniele Roberto GiacobbeClaudio Viscoli
Sep 12, 2019·Revista Da Sociedade Brasileira De Medicina Tropical·Fareeha HameedTayyab Ur Rehman
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Aug 8, 2021·The Science of the Total Environment·Shaqiu ZhangAnchun Cheng

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