Chromosome 14 alteration is associated with increased collagenase expression and the metastatic potential of murine melanomas

Cancer Genetics and Cytogenetics
B J DaveS Pathak

Abstract

The purpose of this study was to correlate abnormalities in chromosome 14 with the invasive metastatic phenotype of K-1735 murine melanoma cells. Low metastatic K-1735 clone 10 and clone 23 cells were transfected with either basic fibroblast growth factor (bFGF), Kaposi's fibroblast growth factor (kFGF), or c-H-ras gene. A high number of bFGF- and H-ras-transfected cells exhibited chromosome 14 rearrangements. These cells also had increased expression of collagenase IV. The kFGF-transfected cells were highly metastatic but did not have increased expression of collagenase type IV. The kFGF-transfected cells were highly metastatic but did not have increased expression of collagenase type IV, nor abnormalities in chromosome 14. The data imply that karyotypic changes in chromosome 14 are associated with increase expression of collagenase type IV.

References

Sep 15, 1992·Cancer·S Pathak
May 10, 1991·International Journal of Cancer. Journal International Du Cancer·C Sreekantaiah, A A Sandberg
Jan 1, 1988·Clinical & Experimental Metastasis·J E PriceI J Fidler
Mar 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·R S KerbelM L Breitman
Apr 15, 1983·International Journal of Cancer. Journal International Du Cancer·M F Di RenzoP M Comoglio
Jul 1, 1983·Analytical Biochemistry·A P Feinberg, B Vogelstein
Jul 23, 1982·Science·J E TalmadgeI J Fidler
Jan 10, 1980·Nature·G Poste, I J Fidler
Sep 1, 1995·Cancer Genetics and Cytogenetics·S PathakP K Gadhia
Jan 1, 1995·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·R K SinghR Radinsky

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Citations

May 20, 1998·Cancer Investigation·C J DimitroffR J Bernacki

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