PMID: 9178811May 16, 1997Paper

Chromosome 16 in primary prostate cancer: a microsatellite analysis

International Journal of Cancer. Journal International Du Cancer
I OsmanC Cordon-Cardo

Abstract

Cytogenetic and molecular genetic analyses of prostate cancer specimens have revealed nonrandom chromosomal deletions, affecting chromosomes 7q, 8p, 10q and 16q. Based on these data, we designed this study to further characterize the altered region(s) on chromosome 16 by evaluating 16 microsatellite markers on a population composed of 32 paired normal and primary prostatic tumor samples. The 16 microsatellites selected mapped to 11 distinct loci on 16q and 5 loci on 16p. No alterations were identified affecting 16p. However, 16 of 31 (51%) informative cases showed molecular alterations in at least one of the loci analyzed on 16q, consisting of 18 deletions and 11 bandshifts. Moreover, most of the deletions clustered at 6 microsatellite loci, mapping to the 16q22.1-23.1 region. Our results suggest that microsatellite alterations on the long arm of chromosome 16 are frequent events in prostate cancer, and that the 16q22.1-23.1 region might harbor a tumor suppressor gene involved in prostate cancer.

References

Jan 1, 1992·Genes, Chromosomes & Cancer·R LundgrenF Mitelman
Oct 29, 1992·Nature·J WeissenbachM Lathrop
Nov 1, 1991·Genomics·K KunimiV P Collins
May 1, 1991·Genes, Chromosomes & Cancer·U S BergerheimP Ekman
Nov 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·B S CarterW B Isaacs
Oct 9, 1987·Science·E R FearonB Vogelstein
Feb 1, 1994·Genes, Chromosomes & Cancer·A M Cleton-JansenC J Cornelisse
Jun 1, 1994·Nature Genetics·G GyapayJ Weissenbach
Aug 21, 1993·Lancet·G DalbagniC Cordon-Cardo
Apr 22, 1996·International Journal of Cancer. Journal International Du Cancer·L LacombeC Cordon-Cardo

❮ Previous
Next ❯

Citations

Aug 6, 1999·Cancer Investigation·R S VermaC J Godec
Mar 11, 2000·American Journal of Human Genetics·B K SuarezW J Catalona
Dec 10, 2002·International Journal of Cancer. Journal International Du Cancer·Dev KaranSurinder K Batra
Jul 9, 1999·The Journal of Pathology·E BraungartM J Atkinson
Jul 27, 1999·International Journal of Cancer. Journal International Du Cancer·S M MietC Marçais
Apr 9, 2005·Experimental Cell Research·R BauerA K Bosserhoff
Jun 29, 2000·Medical Oncology·S N PentyalaS A Khan
Nov 12, 2005·Journal of Cancer Research and Clinical Oncology·Tamara CacevSanja Kapitanović
Feb 27, 1999·Endocrine Reviews·E RuijterJ Schalken
Feb 20, 2020·Prostate Cancer and Prostatic Diseases·Xiaoyu WangJanet L Stanford

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.