PMID: 11340571May 8, 2001Paper

Chromosome 16q deletion and loss of E-cadherin expression in Hodgkin and Reed-Sternberg cells

International Journal of Cancer. Journal International Du Cancer
K OhshimaM Kikuchi

Abstract

Hodgkin and Reed-Sternberg (H&RS) cells are generally considered to be the neoplastic cells of Hodgkin's disease (HD); however, such H&RS cells are a few in number due to the numerous reactive cells. Very few data have so far been published on the cytogenetic abnormalities in HD. We have previously used the analysis of comparative genomic hybridization (CGH), employing sorted H&RS cells. The most commonly observed genetic aberrations were a loss on 16q11/21, a gain on 1p13 and a gain on 7q35/36. To confirm the loss of 16q, we analyzed the loss of heterozygosity (LOH) using the regions D16S3075 (16p13), D16S3068 (16q11), D16S3136 (16q12), D16S503 (16q13), D16S515 (16q21), D16S3091 (16q23) and D16S520 (16q24). A total of 100 sorted H&RS cells were compared with a similar number of sorted reactive T cells in 15 cases with HD, including 5 cases with nodular sclerosis (NS) type and 10 cases with mixed cellularity (MC) type. LOHs of 16q, especially 16q21-23, were frequently detected, but 16p deletions were infrequent. Analysis of 16q21 showed LOH in 12 of 15 cases with HD (80%), including 9 cases with MC type (90%) and 3 cases with NS type (60%). 16q23 showed LOH in 9 of 15 cases with HD (60%), including 5 cases with MC type (50%) an...Continue Reading

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Citations

Jun 22, 2006·International Journal of Hematology·Marc A WenigerPeter Möller
Dec 6, 2008·Veterinary Clinical Pathology·Bente FlatlandRoslyn H Casimir
Jul 8, 2010·Genes, Chromosomes & Cancer·Annette SchmidtRalf Küppers
Dec 24, 2005·Pathology·Lynda J Campbell
Dec 17, 2014·Immunological Reviews·Anagh A Sahasrabuddhe, Kojo S J Elenitoba-Johnson
May 11, 2016·Journal of Molecular Histology·Chengjin ZhaoXiubing Zhang
May 26, 2016·Seminars in Cancer Biology·Marc A Weniger, Ralf Küppers
Dec 27, 2005·Carcinogenesis·M Matabuena de YzaguirreJ Fernández-Piqueras

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