Chromosome 1p aberrations are frequent in human primary hepatocellular carcinoma

Cancer Genetics and Cytogenetics
H L ChenD S Chen

Abstract

To investigate the chromosomal changes in hepatocellular carcinoma in humans, metaphase chromosomes obtained directly from short-term culture of resected human primary hepatocellular carcinoma tissues were studied in seven patients. Among the five successfully karyotyped cases, cytogenetic analysis showed highly different and complex chromosomal changes in the cancer tissue in four patients. Structural aberrations of chromosome 1 and deletion of 1p with breakpoints at p22 or p32 were the most common abnormalities, and were found in the four successfully analyzed cases. Loss of 1p may be important in hepatocarcinogenesis, and warrants further characterization by molecular genetic analysis.

References

Feb 1, 1992·Cancer Genetics and Cytogenetics·G BardiF Mitelman
Jan 1, 1992·Genes, Chromosomes & Cancer·T PejovicH Willén
May 10, 1991·International Journal of Cancer. Journal International Du Cancer·C Sreekantaiah, A A Sandberg
Apr 1, 1990·Cancer Genetics and Cytogenetics·D SimonB B Knowles
Nov 1, 1989·Genes, Chromosomes & Cancer·A WeithM Schwab
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·C T FongG M Brodeur
Sep 1, 1987·Cancer Genetics and Cytogenetics·T C Hsu
Oct 30, 1971·Lancet·M Seabright
Jul 15, 1982·International Journal of Cancer. Journal International Du Cancer·D SimonB B Knowles
Feb 1, 1993·Cancer Genetics and Cytogenetics·H L ChenD S Chen

❮ Previous
Next ❯

Citations

Oct 24, 2001·Cancer Genetics and Cytogenetics·S H KooG Kong
Oct 14, 2003·Cancer Genetics and Cytogenetics·Sun Hoe KooJong Wan Kim
Aug 11, 2000·Seminars in Cancer Biology·M A Buendia
Dec 24, 2002·The Prostate·Terence W McGarveyS Bruce Malkowicz
Oct 26, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·N WongP J Johnson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.