Chromosome 9p deletions identify an aggressive phenotype of clear cell renal cell carcinoma

Cancer
Jeffrey La RochelleAllan J Pantuck

Abstract

The authors investigated whether deletion of chromosome 9p in clear cell renal cell carcinoma (ccRCC) predicted worse disease-specific survival (DSS) and recurrence-free survival (RFS) and whether it was associated with more aggressive behavior in small renal masses. In total, 703 ccRCC tumors were analyzed using fluorescence in situ hybridization (316 tumors) and cytogenetics (388 tumors). Tumor grade, classification, and size; 9p status; Eastern Cooperative Oncology Group performance status (ECOG PS); lymph node involvement; and the presence of metastasis were recorded. Outcomes were stratified by 9p status, and a Cox proportional hazards models was constructed using TNM staging, ECOG PS, tumor size, tumor grade, and 9p status. Deletions of 9p were detected in 97 tumors (13.8%). At presentation, 9p-deleted tumors were larger and were more likely to be high grade (grade 3 or 4), to have a high tumor (T) classification (T3-T4), and to have lymph node or distant metastases (P < .01). The median DSS for patients with and without 9p deletions was 37 months and 82 months, respectively (P < .01). In patients with localized disease, the median RFS in those who had 9p deletions was 53 months and was not reached in those without 9p del...Continue Reading

References

Oct 17, 2002·Journal of the National Cancer Institute·Masahiro YaoKei-Ichi Kondo
May 18, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Michael AtkinsSabina Signoretti
Sep 21, 2006·Journal of the National Cancer Institute·John M HollingsworthBrent K Hollenbeck
Feb 14, 2007·The Journal of Urology·David A KunkleRobert G Uzzo
Jun 15, 2007·The Journal of Urology·Alessandro VolpeMichael A S Jewett
Oct 2, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Matteo BrunelliGuido Martignoni
Mar 18, 2008·The Journal of Urology·Tobias KlatteAllan J Pantuck
May 9, 2008·International Journal of Cancer. Journal International Du Cancer·Jean-Jacques PatardAllan J Pantuck
Sep 9, 2008·Urologic Oncology·Tobias KlatteAllan J Pantuck
Jan 7, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Tobias KlatteAllan J Pantuck

❮ Previous
Next ❯

Citations

Sep 7, 2013·Journal of Inorganic Biochemistry·Luisana AstudilloJaroslava Miksovska
Jul 5, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Federico A MonzonEric Jonasch
Nov 22, 2011·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Miha Pavšič, Brigita Lenarčič
May 29, 2012·Molecular Cancer Research : MCR·Eric JonaschW Kimryn Rathmell
Jun 12, 2012·European Urology·Tobias Klatte
Jul 19, 2011·Cancer Genetics·Jill M HagenkordFederico A Monzon
May 30, 2013·The Journal of Pathology·Pierre MartinezCharles Swanton
Jun 30, 2011·Cancer·Michela de MartinoMichael Marberger
Oct 19, 2013·International Journal of Cancer. Journal International Du Cancer·F DugayM A Belaud-Rotureau
Nov 28, 2015·Surgical Pathology Clinics·Michelle S HirschPaola Dal Cin
Oct 9, 2015·BioMed Research International·Ning Yi YapGlenda Carolyn Gobe
Jul 1, 2015·Current Opinion in Urology·Aspasia SoultatiSamra Turajlic
Jun 4, 2015·Clinical & Experimental Metastasis·Nicole M White-Al HabeebGeorge M Yousef
Oct 29, 2015·Applied Immunohistochemistry & Molecular Morphology : AIMM·Francesco MassariMatteo Brunelli
Mar 1, 2018·Der Urologe. Ausg. A·R MagerA Haferkamp
Jul 25, 2019·Molecular Diagnosis & Therapy·Vincenzo Di NunnoFrancesco Massari
Apr 10, 2020·JCI Insight·Nirmish SinglaJames Brugarolas
May 11, 2017·Virchows Archiv : an International Journal of Pathology·Julien DagherMarc-Antoine Belaud-Rotureau
Jan 15, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Benoit BeuselinckJessica Zucman-Rossi
Mar 19, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·David D Chism, W Kimryn Rathmell
Nov 5, 2020·Nature Reviews. Nephrology·Eric JonaschW Kimryn Rathmell
Mar 7, 2021·International Journal of Molecular Sciences·Flávia Gonçalves FernandesAdriane Feijó Evangelista

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adenocarcinoma, Clear Cell

Clear Cell Adenocarcinoma is a tumor that arises in the female genital tract and is characterized by cells that appear clear under the microscope. Discover the latest research here.

Related Papers

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Tobias KlatteAllan J Pantuck
Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Tobias KlatteArie S Belldegrun
© 2021 Meta ULC. All rights reserved