PMID: 9416788Jan 7, 1998Paper

Chromosome aberration frequencies in human lymphocytes irradiated in a multi-layer array by protons with different LET

International Journal of Radiation Biology
E SchmidM Bauchinger

Abstract

To provide data on the dose-and linear energy transfer (LET)-dependence of the production of dicentrics in human lymphocytes. Track segment irradiation with 16.5 MeV protons was performed in a multi-layer array allowing the simultaneous exposure of human peripheral lymphocytes in three successive samples. Within these samples the dose-averaged linear energy transfer (LD) of protons increased with increasing depth, i.e. LD = 3.5, 5.3 and 19.0 keV/microm. Dicentrics were scored in first division solid-stained metaphases. Dicentric yields measured in the first and second samples fit the linear-quadratic model, those of the third sample fit a linear model of the dose response relationship. Relative to 137Cs gamma-rays, limiting RBE values of 2.9, 4.3 and 21.5 were determined from the ratios of the respective linear coefficients of the dose effect curves. The linear dose effect coefficient increases approximately proportionally with increasing LET. The quadratic coefficient is approximately constant for protons with LD of 3.5 and 5.3 keV/microm, and is not significantly different from zero at LD= 19.0 keV/microm. This result is well in line with theoretical predictions on the variations of dose-effect coefficients with radiation qua...Continue Reading

References

Dec 1, 1990·International Journal of Radiation Biology·G R RimplM Bauchinger
Jul 1, 1986·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·A A EdwardsJ E Moquet

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Citations

Feb 12, 2009·International Journal of Radiation Biology·M S Sasaki
Jun 23, 2005·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Paola Scampoli
Nov 4, 1998·Medical Physics·R K Sachs, D J Brenner
May 26, 2006·Physics in Medicine and Biology·L M GarciaG P Raaphorst
Jan 10, 2019·Radiation Protection Dosimetry·Yoshitaka MatsumotoHideyuki Sakurai
May 2, 2000·Radiation Research·E H KajiokaD S Gridley
May 12, 2011·Radiation Research·Viktorie StisovaBetsy M Sutherland
Nov 4, 2009·Radiation Research·T E SchmidB Röper
Aug 3, 2004·Physics in Medicine and Biology·J J Wilkens, U Oelfke
Nov 6, 2015·Frontiers in Oncology·Kerry A GeorgeFrancis A Cucinotta
Apr 25, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Fredrik KalholmNiels Bassler

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