PMID: 9525254Apr 3, 1998Paper

Chromosome aberration frequencies in human lymphocytes irradiated in a phantom by a mixed beam of fission neutrons and gamma-rays

International Journal of Radiation Biology
E SchmidM Bauchinger

Abstract

To provide further information on the existence of a significant quadratic component of the dose response relationship for the production of dicentrics in human lymphocytes by mixed fission neutron and gamma-ray irradiation, which has been observed previously employing the same beam under free-in-air conditions. Irradiation of blood samples and dosimetry was performed at 2 cm depth in a polymethyl methacrylate (PMMA) phantom of 16 cm side-length where the PMMA material fully surrounded the blood specimen. Chromosome analysis was carried out exclusively in complete first division metaphases. Dicentric yields induced by absorbed doses between 0.043 and 2.68 Gy fit a linear-quadratic model with a quadratic coefficient significantly different from zero. The distribution of dicentrics is overdispersed compared to Poisson at lower doses, but is poissonian at higher doses. The presence of a significant quadratic dose response coefficient for dicentrics, both for free-in-air and phantom irradiation, is caused by the various degraded fission spectra that produce neutrons or recoil protons over a broad energy range, rather than by the gamma-ray component of the beam.

Citations

Nov 29, 2011·Radiation Oncology·Sylvia GarnyHerwig G Paretzke
Sep 11, 2016·Journal of Radiation Research·Masao S SasakiTaisei Nomura
Nov 15, 2003·Annals of the ICRP·UNKNOWN Task Group on Radiation Quality Effects in Radiological Protection, Committee 1 on Radiation Effects, International Commissi
Dec 25, 2008·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Franz M WagnerWinfried Petry
Jul 10, 1999·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·A A Edwards

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