Chromosome aberrations and sister chromatid exchange studies in patients with prostate cancer: possible evidence of chromosome instability

Cancer Genetics and Cytogenetics
V S Dhillon, I K Dhillon

Abstract

Cytogenetic studies have been carried out using the G-banding technique in peripheral blood lymphocytes of 24 patients with prostate cancer. Of these, eight belong to stage B, six to stage C/e, three to C/sv, two to Do, and the remaining five to DI stage of carcinoma. Simultaneously, sister chromatid exchanges (SCEs) were also analyzed in the peripheral blood lymphocytes of these patients, along with those of 40 age-matched control subjects. The frequency of aberrant metaphases is significantly higher in patients with prostate cancer (7.32%) than in age-matched controls (2.92%). A large number of chromosome aberrations in lymphocytes of these patients, which are generally constitutional in nature, have also been detected. In stage-B patients, the frequency of cytogenetically abnormal cells is comparatively low with regard to the number of cells scanned, and these abnormalities are generally confined only to single chromosome (except in one metaphase in patient 1, who was diagnosed with bladder carcinoma in addition to cancer of the prostate). Sister chromatid exchanges (SCEs) were also analyzed in the patients and age-matched control subjects. The mean SCE frequencies were 9.24 +/- 0.62 (n = 1356) per metaphase and 0.203 per ch...Continue Reading

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Dec 22, 2006·Bulletin of Experimental Biology and Medicine·O A BocharovaN P Bochkov
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