Chromosome aberrations and their relevance to metal carcinogenesis

Environmental Health Perspectives
H Vainio, M Sorsa

Abstract

Scoring for structural chromosome abnormalities is one of the only practical methods available for detecting visual damage in human genetic material. Cytogenetic tests in vivo and in vitro have shown the clastogenic potential of a number of metals and metal compounds. The difficulties in in vivo studies lie in identifying a specific clastogen in an occupational setting, where simultaneous exposure to a number of organic and inorganic chemicals is a common phenomenon. Metals known to be carcinogens in animals also tend to possess chromosome-damaging properties, even though more extensive studies are needed before any conclusive evidence can be reached. The visible chromosomal damage produced by exposure to metal compounds should be considered as a warning indication of potentially adverse genetic and somatic effects in humans.

Associated Clinical Trials

References

Jul 18, 1979·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·F Vogel
Aug 4, 1979·Lancet·B HögstedtA Schütz
Sep 1, 1979·Mutation Research·M HollsteinW W Nichols
Apr 1, 1975·Environmental Research·T H BuiG F Nordberg
Jan 1, 1979·Annals of the New York Academy of Sciences·J C McDonald, F D Liddell
Aug 1, 1979·Mutation Research·T WatanabeA Endo
Jun 8, 1979·Archives of Toxicology·M R Moore, P A Meredith
Apr 17, 1979·Human Genetics·I NordensonG Beckman
Jul 24, 1979·Pediatric Radiology·J E PolletF W Smith
Jun 1, 1979·Environmental Research·D Picciano
Dec 1, 1977·Journal of Toxicology and Environmental Health·G DeknudtG B Gerber
Nov 1, 1978·Chemico-biological Interactions·R L TyndallC A Burtis
Nov 1, 1978·Mutation Research·M L O'RiordanH J Evans
Jan 1, 1975·Hereditas·W W Nichols
Jan 1, 1976·Annals of the New York Academy of Sciences·L A HarkerJ Glomset
May 1, 1977·Journal of Toxicology and Environmental Health·L D KollerB Arbogast
Dec 1, 1976·Environmental Research·L VerschaeveD Roossels
Dec 15, 1976·International Archives of Occupational and Environmental Health·J B Bijlsma, H F de France
Jan 1, 1976·Annals of the New York Academy of Sciences·D G JamesL E Siltzbach
May 2, 1975·Deutsche medizinische Wochenschrift·G SchwanitzH Prestele
Mar 1, 1976·Archives of Environmental Health·A ForniG C Secchi
Dec 1, 1973·Journal of the Science of Food and Agriculture·D C Kirkpatrick, D E Coffin
Nov 1, 1972·Mutation Research·G R Paton, A C Allison
Dec 1, 1972·Mutation Research·M BauchingerD Schmidt
Nov 1, 1971·Archives of Environmental Health·A M ForniE C Vigliani
Jan 9, 1970·Deutsche medizinische Wochenschrift·J PetresU Wolf
Jan 15, 1970·International Journal of Cancer. Journal International Du Cancer·M K Jensen
Aug 7, 1970·Deutsche medizinische Wochenschrift·G SchwanitzE Gebhart
Jan 1, 1980·Mutation Research·A Léonard, R R Lauwerys
Jan 1, 1980·Hereditas·K Husgafvel-PursiainenM Sorsa

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Citations

Aug 1, 1981·Environmental Health Perspectives·K S Squibb, B A Fowler
Aug 1, 1981·Environmental Health Perspectives·T G Rossman
Jun 19, 2008·Cancer Causes & Control : CCC·Andrea L RossoUNKNOWN Children's Oncology Group
Sep 13, 2011·Reviews on Environmental Health·Keyuna S CameronPaul B Tchounwou
Jan 1, 1983·Cancer Metastasis Reviews·S R Wolman
Jan 1, 1992·Mutation Research·J P WiseS R Patierno
May 1, 1991·Biological Trace Element Research·S PalitG Talukder
Jul 1, 1986·European Journal of Biochemistry·K Gausing, R Barkardottir

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