PMID: 7536456Mar 1, 1995Paper

Chromosome analysis of 97 primary breast carcinomas: identification of eight karyotypic subgroups

Genes, Chromosomes & Cancer
N PandisF Mitelman

Abstract

Chromosome banding analysis of 97 short-term cultured primary breast carcinomas revealed clonal aberrations in 79 tumors, whereas 18 were karyotypically normal. In 34 of the 79 tumors with abnormalities, two to eight clones per case were detected; unrelated clones were present in 27 (34%) cases, whereas only related clones were found in seven. These findings indicate that a substantial proportion of breast carcinomas are of polyclonal origin. Altogether eight abnormalities were repeatedly identified both as sole chromosomal anomalies and as part of more complex karyotypes: the structural rearrangements i(1)(q10), der(1:16)(q10;p10), del(1)(q11-12), del(3)(p12-13p14-21), and del(6)(q21-22) and the numerical aberrations +7, +18, and +20. At least one of these changes was found in 41 (52%) of the karyotypically abnormal tumors. They identify a minimum number of cytogenetic subgroups in breast cancer and are likely to represent primary chromosome anomalies in this type of neoplasia. Other candidates for such a role are translocations of 3p12-13 and 4q21 with various partner chromosomes and inversions of chromosome 7, which also were seen repeatedly. Additional chromosomal aberrations that give the impression of occurring nonrandoml...Continue Reading

References

Jul 1, 1992·Genes, Chromosomes & Cancer·N PandisF Mitelman
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Citations

Aug 12, 1998·International Journal of Cancer. Journal International Du Cancer·A AdeyinkaN Pandis
Aug 26, 1998·International Journal of Cancer. Journal International Du Cancer·A NarayanM Ehrlich
Jul 15, 1999·International Journal of Cancer. Journal International Du Cancer·A AdeyinkaN Pandis
Jul 15, 1999·International Journal of Cancer. Journal International Du Cancer·H TsudaS Hirohashi
May 1, 1996·Genes, Chromosomes & Cancer·A AdeyinkaF Mitelman
Aug 1, 1996·Genes, Chromosomes & Cancer·M SchwabL C Amler
Oct 23, 1997·Genes, Chromosomes & Cancer·J S MorrisP A Edwards
Dec 31, 1997·Genes, Chromosomes & Cancer·S J PlummerG Casey
Aug 26, 1998·Genes, Chromosomes & Cancer·M R TeixeiraS Heim
Sep 17, 1998·Genes, Chromosomes & Cancer·J BernardinoB Dutrillaux
Aug 19, 1999·Genes, Chromosomes & Cancer·I BiècheR Lidereau
Aug 28, 2001·The Journal of Pathology·S HeimN Pandis
Sep 19, 2000·Genes, Chromosomes & Cancer·I Fadl-ElmulaS Heim
Jan 25, 2002·Genes, Chromosomes & Cancer·Kristine KleiviManuel R Teixeira
Dec 1, 1995·Genes, Chromosomes & Cancer·I Bièche, R Lidereau
May 7, 2002·International Journal of Cancer. Journal International Du Cancer·Monica AutieroJohn Guardiola
Jan 1, 1996·Journal of Cancer Research and Clinical Oncology·W ZoliA Gasperi-Campani
Nov 1, 1996·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·L James, J Varley
Dec 15, 2000·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Y KomoikeH Koyama
Jul 15, 1995·Cancer Genetics and Cytogenetics·L GorunovaF Mitelman
Jan 1, 1996·Cancer Genetics and Cytogenetics·G RohenU Bonk
May 1, 1996·Cancer Genetics and Cytogenetics·K Anamthawat-JónssonM Steinarsdóttir
Aug 26, 2000·Cancer Genetics and Cytogenetics·P H TanY Chong
Nov 7, 2000·Cancer Genetics and Cytogenetics·M RudasC Marosi
Jun 27, 2001·Cancer Genetics and Cytogenetics·L GorunovaB Johansson
Feb 19, 2002·Cancer Genetics and Cytogenetics·Reza MirfakhraieParvin Mehdipour
Oct 29, 2003·Cancer Genetics and Cytogenetics·Adewale AdeyinkaNikos Pandis
Nov 1, 1996·Cancer Genetics and Cytogenetics·R ValgardsdottirJ E Eyfjörd
May 1, 1997·Cancer Genetics and Cytogenetics·F MitelmanF Mertens
May 1, 1997·Cancer Genetics and Cytogenetics·S HeimN Pandis

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