Chromosome analysis of canine transmissible sarcoma cells

Zentralblatt für Veterinärmedizin. Reihe A
T FujinagaK Otomo

Abstract

The chromosomal banding patterns of canine transmissible sarcoma (CTS) cells were analyzed and compared to those of normal canine cells with four banding techniques. In addition, N-myc and N-ras oncogenes on the chromosomes of the CTS cells were investigated by the in situ hybridization method. The modal chromosome number of the CTS cells was 58:17 metacentrics and 41 acrocentrics. Based on their G- and Q-banding patterns most of the chromosomes of the CTS cells were present in normal cells except for the second largest metacentric chromosomes. It was considered that the metacentric chromosomes of the CTS cells results from Robertsonian translocation of normal chromosomes. The long arm of the second largest metacentric element of the CTS cells was stained negatively by the Q-banding technique. The C-band was found on the long arm of the second largest metacentric element and three pairs of N-bands were recognized in the same region. It was suggested that this amplification of N-bands enhanced tumorigenic properties in the CTS. No N-myc or N-ras oncogenes were detected on chromosomes of the CTS cells by the in situ hybridization method.

References

Sep 1, 1976·Canadian Journal of Genetics and Cytology. Journal Canadien De Génétique Et De Cytologie·M ManolacheM Schmid
Jan 1, 1975·Cytogenetics and Cell Genetics·J R SeldenD F Patterson
Apr 1, 1989·Nihon juigaku zasshi. The Japanese journal of veterinary science·T FujinagaK Otomo
Oct 30, 1971·Lancet·M Seabright
Nov 1, 1972·Experimental Cell Research·A T Sumner
Oct 1, 1973·Journal of the National Cancer Institute·M OshimuraS Makino
Sep 1, 1965·Journal of the National Cancer Institute·W T WeberW C Hare
Sep 1, 1980·Jinrui idengaku zasshi. The Japanese journal of human genetics·Y KodamaM Sasaki
Jul 15, 1983·Science·J J Yunis
Jul 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·N KandaS Latt
Sep 1, 1960·Experimental Cell Research·P S MOORHEADD A HUNGERFORD
Nov 4, 1963·Annals of the New York Academy of Sciences·S MAKINO

❮ Previous
Next ❯

Citations

Oct 3, 2009·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Rachael ThomasMatthew Breen
Jun 1, 1997·Veterinary Immunology and Immunopathology·T MarchalJ P Magnol
Aug 24, 2012·PloS One·Junko MaedaTakamitsu A Kato
Nov 11, 2014·Annual Review of Animal Biosciences·Hannah S BenderJanine E Deakin
Jul 17, 2001·American Journal of Veterinary Research·A SetoguchiH Tsujimoto
Feb 15, 2001·Oncogene·V I Sementchenko, D K Watson
Feb 15, 2001·Oncogene·M Trojanowska
Oct 19, 2005·Cancer Research·Laurent GilletAlain Vanderplasschen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Research in Veterinary Science
B MayrE Eisenmenger
Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
Kuang-Wen LiaoRea-Min Chu
© 2022 Meta ULC. All rights reserved