Chromosome band 6q deletion pattern in malignant lymphomas

Cancer Genetics and Cytogenetics
M TaborelliCarlo Capella

Abstract

Deletion of chromosome arm 6q is a frequent karyotypic alteration found in a variety of cancers and lymphoproliferative disorders, including leukemia and lymphomas. We characterized 6q deletions in 35 malignant lymphomas, using conventional and molecular cytogenetic approaches, to define the deletion pattern of 6q in different histological types. Conventional cytogenetics revealed a 6q deletion in 46% of lymphomas, including two cases that showed 6q deletion as the sole chromosome anomaly. Interphase FISH analysis demonstrated allelic loss of 6q regions in 33 out of 35 cases (94.2%); the deletions were discontinuous, involving nonadjacent molecular regions. Although 6q deletion is a common event in all types of lymphomas, specific deletion patterns seem to characterize different histological types, suggesting that different tumor suppressor genes play different roles in different types of lymphomas. Two specific 6q regions deleted in diffuse large B cell lymphomas but not in follicular lymphomas may be implicated in the clinical transformation.

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Citations

Jun 19, 2013·Best Practice & Research. Clinical Haematology·Yenlin HuangPhilippe Gaulard
May 13, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Esteban BraggioBrian Patrick O'Neill
Nov 22, 2013·PloS One·Anne-Lise PeilleLaurence Bresson-Bepoldin
Feb 26, 2008·Leukemia & Lymphoma·Emma Flordal ThelanderSvetlana Lagercrantz
May 24, 2013·The Journal of Investigative Dermatology·Katarzyna IżykowskaGrzegorz K Przybylski
Mar 14, 2008·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·A Kozłowska, P P Jagodziński
Jun 23, 2007·Environmental and Molecular Mutagenesis·Luoping ZhangMartyn T Smith
Oct 19, 2007·International Journal of Cancer. Journal International Du Cancer·Karina Dalsgaard SørensenNiels Tørring
Jan 26, 2011·Histopathology·Laurence de Leval, Philippe Gaulard
Jul 22, 2010·Cell Biochemistry and Function·Sunhee LeeSoojin Lee
Jan 21, 2014·The Journal of Dermatology·Sanghui Park, Young H Ko
Feb 23, 2010·Genes, Chromosomes & Cancer·Elizabeth M A ValleleyDavid T Bonthron
Feb 4, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jackie Mei-Wah FungXin-Yuan Guan

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