PMID: 6974128Jun 1, 1981Paper

Chromosome changes in the lymphomas

Human Pathology
A A Sandberg

Abstract

A substantial proportion of all lymphomas contain a marker chromosome 14q +. In Burkitt's lymphoma the marker 14q + was shown in the past to be due to a t(8;14)(q24;32). Recent studies have pointed out that 8q - may be more characteristic and more specific for Burkitt's lymphoma than 14q +, since translocations involving chromosome 8 with 2 or 22 (and not 14) have been described in a significant number of cases of Burkitt's lymphoma. Although chromosome 14 appears to be most common recipient of translocated material in non-Burkitt's lymphomas, the donor chromosome may be one of a variety of chromosomes such as 1, 2, 4, 6, 10, 11, 14, and 18. To date, however, no clinical specificity of the donor chromosome in a particular type of lymphoma has been established. It will be necessary to accumulate more such data, and to relate the information to cell markers, histologic features, stage, and therapeutic response in the cases involved, before a more precise classification of the non-Burkitt's lymphomas becomes available.

Citations

Jun 1, 1988·British Journal of Haematology·N TominagaT Abe
Dec 1, 1982·American Journal of Hematology·M GygerL Forest
Nov 11, 1982·The New England Journal of Medicine·J J YunisA Theologides
May 1, 1993·Leukemia & Lymphoma·H NakamineD D Weisenburger
Jul 1, 1988·American Journal of Hematology·T GhoseS H Lee
Oct 1, 1984·Hematological Oncology·J P Lewis, M R MacKenzie
Jul 1, 1990·Acta Pathologica Japonica·K Aozasa
Nov 1, 1983·The American Journal of Medicine·K S Albain, J E Ultmann
Jul 15, 1983·Science·J J Yunis

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