Chromosome Cohesion Established by Rec8-Cohesin in Fetal Oocytes Is Maintained without Detectable Turnover in Oocytes Arrested for Months in Mice.

Current Biology : CB
Sabrina BurkhardtKikuë Tachibana-Konwalski

Abstract

Sister chromatid cohesion mediated by the cohesin complex is essential for chromosome segregation in mitosis and meiosis [1]. Rec8-containing cohesin, bound to Smc3/Smc1α or Smc3/Smc1β, maintains bivalent cohesion in mammalian meiosis [2-6]. In females, meiotic DNA replication and recombination occur in fetal oocytes. After birth, oocytes arrest at the prolonged dictyate stage until recruited to grow into mature oocytes that divide at ovulation. How cohesion is maintained in arrested oocytes remains a pivotal question relevant to maternal age-related aneuploidy. Hypothetically, cohesin turnover regenerates cohesion in oocytes. Evidence for post-replicative cohesion establishment mechanism exists, in yeast and invertebrates [7, 8]. In mouse fetal oocytes, cohesin loading factor Nipbl/Scc2 localizes to chromosome axes during recombination [9, 10]. Alternatively, cohesion is maintained without turnover. Consistent with this, cohesion maintenance does not require Smc1β transcription, but unlike Rec8, Smc1β is not required for establishing bivalent cohesion [11, 12]. Rec8 maintains cohesion without turnover during weeks of oocyte growth [3]. Whether the same applies to months or decades of arrest is unknown. Here, we test whether Re...Continue Reading

References

Feb 15, 1996·Nucleic Acids Research·Y ZhangM Reth
Sep 21, 2001·Molecular and Cellular Biology·E RevenkovaR Jessberger
Jul 24, 2007·Molecular Cell·Dmitri Ivanov, Kim Nasmyth
Nov 6, 2009·Annual Review of Genetics·Kim Nasmyth, Christian H Haering
May 11, 2010·Current Biology : CB·Jill M Heidinger-PauliDouglas Koshland
Oct 26, 2010·Genes & Development·Kikuë Tachibana-KonwalskiKim Nasmyth
Sep 9, 2011·Biology of Reproduction·Xiaohui LiStephanie A Pangas
Jun 19, 2012·Nature Reviews. Genetics·So I NagaokaPatricia A Hunt
Aug 24, 2013·Cell Division·Katarzyna KuleszewiczNobuaki R Kudo
Mar 29, 2014·Cell Death & Disease·Z-Z JiangQ-Y Sun
May 9, 2014·PloS One·Makiko TsutsumiHiroki Kurahashi
Jul 2, 2015·Nature Communications·Yogo SakakibaraTomoya S Kitajima

❮ Previous
Next ❯

Citations

Jun 14, 2016·Current Biology : CB·Mercedes R GyuriczaKim S McKim
Oct 25, 2016·Trends in Cell Biology·Alexandre Webster, Melina Schuh
Apr 27, 2016·Current Biology : CB·Attila Toth, Rolf Jessberger
Jul 25, 2017·International Journal of Molecular Sciences·Jin-Mei Cheng, Yi-Xun Liu
May 17, 2018·PLoS Genetics·Margarita R HernandezGyörgyi Csankovszki
Aug 15, 2017·Chromosoma·Masashi HadaYuki Okada
Nov 28, 2018·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Kei-Ichiro Ishiguro
Dec 9, 2017·The EMBO Journal·Johanna GasslerKikuë Tachibana
Apr 9, 2020·Molecular Biology of the Cell·Tara M Little, Philip W Jordan
Feb 1, 2018·Biology of Reproduction·Ewelina Bolcun-Filas, Mary Ann Handel
Dec 16, 2017·Human Reproduction Update·Jessica GreaneyHayden Homer
May 21, 2019·ELife·Maria A PrusickiArp Schnittger
Dec 20, 2018·Cellular and Molecular Life Sciences : CMLS·Simon Lane, Liisa Kauppi
Apr 18, 2020·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Congcong ZhangAndrea L J Marschall
Apr 29, 2019·Chromosoma·Peera Wasserzug-Pash, Michael Klutstein
Jun 17, 2020·Essays in Biochemistry·Binyam Mogessie
Oct 3, 2020·Journal of Assisted Reproduction and Genetics·Cristina Quesada-CandelaJudith L Yanowitz
Jan 16, 2021·Biochemical Society Transactions·Christopher ThomasMelina Schuh
Nov 14, 2020·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Jun-Yu MaQing-Yuan Sun
Apr 17, 2021·Prenatal Diagnosis·Lena WartoschJinchuan Xing
May 4, 2021·Frontiers in Cell and Developmental Biology·Shenae L CafeElizabeth G Bromfield
Jul 16, 2021·Nature Communications·Christopher ThomasSuzanne Madgwick
Jul 28, 2021·Current Biology : CB·Emmanouella E ChatzidakiKikuë Tachibana
Aug 20, 2021·Frontiers in Cell and Developmental Biology·Rachel BeverleyMiguel Angel Brieño-Enríquez

❮ Previous
Next ❯

Methods Mentioned

BETA
Assay
PCR
genotyping
transgenic

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.