Chromosome damage in peripheral lymphocytes of sheep induced by chlorine in drinking water

International Journal of Environmental Health Research
Irena SutiakováJana Porácová

Abstract

The potential of chromosomal damage associated with the effects of chlorine in drinking water was evaluated using chromosome aberrations and micronuclei as cytogenetic endpoints in the lymphocytes of peripheral blood of ewe lambs. The study assessed the in vivo effects of high chlorine doses (1.8 mg l(-1), based on Savo-Super disinfectant) in drinking water on the peripheral lymphocytes of sheep after 30 days. The frequency of aberrant cells (AB.C.) in the experimental and control groups was 31.80+/-13.68% AB.C. and 4.50+/-2.07% AB.C. respectively, and the increased AB.C. in the treated group was highly significant (P=/<0.001). In the experimental group chromatid breaks (26.20+/-10.47%) and gaps (24.20+/-13.94%) were the dominant types of aberrations, but statistically significant chromosome gaps and exchanges were also present. The frequency of micronuclei in peripheral lymphocytes of sheep in the control group was 21.17+/-4.36 per 1,000 binucleated cells and 64.20+/-22.51 per 1,000 binucleated cells in the experimental group. A significant increase in the frequency of micronuclei in peripheral lymphocytes of sheep was observed between the two groups (P=0.001).

References

Sep 1, 1991·Journal of Toxicology and Environmental Health·C A Snyder, C D Valle
Nov 1, 1988·Mutation Research·J R Meier
Feb 1, 1985·Mutation Research·M Fenech, A A Morley
Jul 1, 1995·Archives of Environmental Health·M KoivusaloJ J Jaakkola
Aug 1, 1997·Mutation Research·J Surrallés, A T Natarajan
Mar 25, 1999·Environmental Health Perspectives·W H van der SchalieW S Stokes
Mar 11, 2000·Occupational and Environmental Medicine·M J NieuwenhuijsenP Elliott
Mar 16, 2000·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·F X van Leeuwen
Jun 19, 2001·Occupational and Environmental Medicine·J J JaakkolaE Dybing
Jul 4, 2001·Cytogenetics and Cell Genetics·E P CribiuJ Womack
Aug 17, 2001·Mutation Research·S BonassiR Puntoni
Mar 22, 2002·Mutation Research·Stefano Bonassi, William W Au
Jul 11, 2002·Mutation Research·A T Natarajan
Jul 11, 2002·Mutation Research·G ObeM E Drets
Dec 31, 2002·Toxicology·Michael Fenech
Jun 13, 2003·Environmental and Molecular Mutagenesis·S MonarcaI Zerbini

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Citations

Sep 19, 2019·Toxicology Mechanisms and Methods·Satyanarayana Achanta, Sven-Eric Jordt

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