Chromosome painting reveals that galagos have highly derived karyotypes

American Journal of Physical Anthropology
Roscoe StanyonS Consigliere

Abstract

The differences in chromosome number between Otolemur crassicaudatus (2n = 62) and Galago moholi (2n = 38) are dramatic. However, the total number of signals given by hybridizing human chromosome paints to galago metaphases is similar: 42 in O. crassicaudatus and 38 G. moholi. Many human chromosome homologs are found fragmented in each species, and numerous translocations have resulted in chromosomal syntenies or hybridization associations which differ from those found in humans. Only 7 human autosomes showed conserved synteny in O. crassicaudatus, and 9 in G. moholi. Both galago species have numerous associations or syntenies not found in humans: O. crassicaudatus has 11, and G. moholi has 21. The phylogenetic line leading to the last common ancestor of the two galago species accumulated 6 synapomorphic fissions and 5 synapomorphic fusions. Since the divergence of the two galago species, 10 Robertsonian translocations have further transformed the G. moholi karyotype, and 2 fissions have been incorporated into the O. crassicaudatus karyotype. Comparison with other primates, tree shrews, and other mammals shows that both galagos have karyotypes which are a mixture of derived and conserved chromosomes, and neither has a karyotype...Continue Reading

References

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Citations

Mar 18, 2006·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Jianping YeFengtang Yang
Feb 23, 2008·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·R StanyonN Archidiacono
Nov 17, 2004·Cytogenetic and Genome Research·M A Ferguson-SmithP C M O'Brien
Nov 17, 2004·Cytogenetic and Genome Research·A WeiseT Liehr
Jul 20, 2006·PLoS Genetics·Marta SvartmanRoscoe Stanyon
Nov 9, 2004·Current Opinion in Genetics & Development·Johannes Wienberg
Nov 4, 2004·Trends in Genetics : TIG·William J MurphyStephen J O'Brien
Jul 26, 2005·Genomics·William J MurphyStephen J O'Brien
May 4, 2016·Evolution; International Journal of Organic Evolution·David A BaumWilliam Saucier
Aug 8, 2012·Cytogenetic and Genome Research·M Svartman, R Stanyon

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