Chromosome positioning and male infertility: it comes with the territory

Journal of Assisted Reproduction and Genetics
Zaida SarrateJoan Blanco

Abstract

The production of functional spermatozoa through spermatogenesis requires a spatially and temporally highly regulated gene expression pattern, which in case of alterations, leads to male infertility. Changes of gene expression by chromosome anomalies, gene variants, and epigenetic alterations have been described as the main genetic causes of male infertility. Recent molecular and cytogenetic approaches have revealed that higher order chromosome positioning is essential for basic genome functions, including gene expression. This review addresses this issue by exposing well-founded evidences which support that alterations on the chromosome topology in spermatogenetic cells leads to defective sperm function and could be considered as an additional genetic cause of male infertility.

References

Nov 1, 1991·Human Genetics·W MosgöllerJ S Heslop-Harrison
Jan 1, 1993·Cold Spring Harbor Symposia on Quantitative Biology·T CremerP Lichter
May 1, 1995·Chromosoma·A O ZalenskyE M Bradbury
Mar 1, 1994·Human Genetics·A R LeitchJ S Heslop-Harrison
Oct 6, 1999·The Journal of Cell Biology·P J VerschureR van Driel
Oct 9, 1999·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·C Metzler-GuillemainM G Mattei
Feb 5, 2000·Molecular Reproduction and Development·M HazzouriB Sèle
Feb 19, 2000·Current Biology : CB·J M BridgerW A Bickmore
Jun 27, 2000·Biophysical Journal·H B SunH Yokota
May 8, 2002·The Journal of Cell Biology·Nicola L MahyWendy A Bickmore
Jul 9, 2002·Human Reproduction Update·A Van SteirteghemI Liebaers
Dec 25, 2002·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·E LukásováJ Amrichová
Sep 16, 2003·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Ian K GreavesJennifer A Marshall Graves
Sep 16, 2003·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Tobias RagoczySteven T Kosak
Apr 1, 2004·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Irina A Zalenskaya, Andrei O Zalensky
Jun 30, 2004·Blood Cells, Molecules & Diseases·Gabriela GaliováStanislav Kozubek
Jul 9, 2004·Genome Biology·Luis A ParadaTom Misteli
Nov 4, 2004·Genetica·Soledad BerríosM Cristina Cerda
Feb 11, 2005·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Lyudmila Solov'evaAndrei O Zalensky
Apr 1, 2005·Nature·Sarah Kimmins, Paolo Sassone-Corsi
Sep 20, 2005·Reproductive Biomedicine Online·Mohammad Hossein Nasr-EsfahaniMohammad Mardani
Sep 24, 2005·Journal of Cell Science·Olga MudrakAndrei Zalensky
Jul 4, 2006·Reproduction : the Official Journal of the Society for the Study of Fertility·Natalya A SmirnovaR Daniel Camerini-Otero
Jan 26, 2007·Nature·Karen J Meaburn, Tom Misteli
May 22, 2007·Biochemical Society Transactions·A Zalensky, I Zalenskaya
Jun 21, 2007·Reproductive Biomedicine Online·Alberto FerlinCarlo Foresta
Oct 16, 2007·Current Opinion in Genetics & Development·Giacomo Cavalli
Nov 28, 2007·Australian Critical Care : Official Journal of the Confederation of Australian Critical Care Nurses·Glenn Gardner
Feb 8, 2008·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Ewa WilandMaciej Kurpisz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
Anilkumar Bettegowda, Miles F Wilkinson
Journal of Child and Adolescent Psychiatric and Mental Health Nursing
E C Poster, B P Randell
Systems Biology in Reproductive Medicine
D T Carrell
American Journal of Human Genetics
M OkabeJ Ashkenas
© 2022 Meta ULC. All rights reserved