Chromosome size differences may affect meiosis and genome size

Science
John WangLaurent Keller

Abstract

Genetic crosses in many organisms have shown that alleles of unlinked genes generally assort independently of one another during gamete formation. However, variation in chromosome size may affect the process of meiosis and lead to nonindependent assortment of chromosomes. We therefore examined chromosomes with insertions and found that they preferentially segregated away from the X chromosome during meiosis in Caenorhabditis elegans males. Conversely, chromosomes with deletions preferentially segregated with the X chromosome. The degree of segregation bias was significantly associated with the length of the insertion or deletion. Simulations revealed that this segregation bias leads to genome size reduction in hermaphroditic species, a pattern consistent with differences in genome sizes in the genus Caenorhabditis. These results suggest that insertions and deletions may affect chromosome segregation patterns.

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Citations

Nov 23, 2011·Proceedings of the National Academy of Sciences of the United States of America·Alana V BeadellEric S Haag
Apr 7, 2012·Trends in Genetics : TIG·Cristel G ThomasEric S Haag
Dec 14, 2011·Trends in Genetics : TIG·Matthew T Webster, Laurence D Hurst
Sep 12, 2015·Proceedings. Biological Sciences·Göran ArnqvistJ Spencer Johnston
Mar 1, 2015·International Journal for Parasitology·Lotta-Riina Sundberg, Katja Pulkkinen
Oct 30, 2012·Current Biology : CB·Cristel G ThomasEric S Haag
Jun 14, 2016·Molecular Reproduction and Development·Ronald E Ellis
Nov 12, 2016·Molecular Biology and Evolution·Yuh Chwen G LeeMia T Levine
Aug 12, 2018·Nature Communications·Natsumi KanzakiTaisei Kikuchi
May 6, 2014·Genetics·Sarah Elizabeth AlbrittonSevinç Ercan
Sep 7, 2019·Genetics·Asher D CutterPatrick C Phillips

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