Chromosome stability, DNA recombination and the BRCA2 tumour suppressor

Current Opinion in Cell Biology
Ashok R Venkitaraman

Abstract

The BRCA2 tumour suppressor works in DNA recombination and repair pathways to preserve genome integrity. Recent progress provides fresh insights into its role as a regulator of the Rad51 recombination protein, underpinning a model in which BRCA2's involvement in chromosome stability and tumour suppression arises from its participation in recombinational processes essential for DNA replication.

References

May 1, 1996·Nature Genetics·P BorkM Nilges
Jan 15, 1997·The EMBO Journal·B MichelM Uzest
May 15, 1997·Genes & Development·A SuzukiT W Mak
Oct 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·M M Cox
Jul 14, 1998·Molecular Cell·K J PatelA R Venkitaraman
Nov 14, 1998·Cell·M SeigneurB Michel
Feb 3, 1999·Annual Review of Genetics·N Rahman, M R Stratton
Nov 26, 1999·Proceedings of the National Academy of Sciences of the United States of America·B H SpainI M Verma
Feb 1, 2000·Trends in Genetics : TIG·P L WelcshM C King
Mar 21, 2000·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·A R Venkitaraman
Apr 8, 2000·Trends in Biochemical Sciences·S C Kowalczykowski
Mar 10, 2001·Molecular Cell·M E MoynahanM Jasin

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Citations

Sep 21, 2002·Microscopy Research and Technique·Dianne C Daniel
Nov 6, 2010·Chromosoma·Bennie B L G Lemmens, Marcel Tijsterman
Jan 16, 2002·Current Opinion in Genetics & Development·Richard Baer, Thomas Ludwig
May 28, 2003·DNA Repair·John Thacker, Małgorzata Z Zdzienicka
Nov 29, 2002·Microbiology and Molecular Biology Reviews : MMBR·Lorraine S Symington
Jul 6, 2004·Genes, Chromosomes & Cancer·Margrét SteinarsdóttirHelga M Ogmundsdóttir
Feb 19, 2005·Journal of Surgical Oncology·Elizabeth A Mittendorf, Christopher R McHenry
Feb 23, 2005·Cancer Letters·John Thacker
Jul 29, 2004·DNA Repair·John Thacker, Małgorzata Z Zdzienicka
Jul 9, 2005·Mutation Research·Jorunn Erla Eyfjord, Sigridur Klara Bodvarsdottir
Dec 19, 2003·Biochemical and Biophysical Research Communications·Nathalie CallensYvan de Launoit
Jul 17, 2003·Clinical Endocrinology·Trisha M ShattuckAndrew Arnold
Dec 14, 2001·Molecular Cell·X B ChenC H McGowan
May 15, 2012·Journal of Molecular Biology·Alissa C MagwoodMark D Baker
Sep 11, 2014·Nutrition and Cancer·Barbara PampaloniMaria Luisa Brandi
Sep 5, 2007·Biochemical and Biophysical Research Communications·Jaewon MinHyunsook Lee
Mar 17, 2007·Critical Reviews in Biochemistry and Molecular Biology·Michael M Cox
Nov 29, 2016·Cell Cycle·Antonio AbeytaToshiyasu Taniguchi
Mar 20, 2004·European Journal of Human Genetics : EJHG·P Devilee
Feb 26, 2004·Oncogene·Duen-Hwa YanMien-Chie Hung
Jan 1, 2012·Biomolecules·Audrey Costes, Sarah A E Lambert
Nov 27, 2002·Scandinavian Journal of Surgery : SJS : Official Organ for the Finnish Surgical Society and the Scandinavian Surgical Society·H EerolaK von Smitten

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