PMID: 11343905DOI: 10.1016/s0955-0674(00)00217-9May 10, 2001Paper
Chromosome stability, DNA recombination and the BRCA2 tumour suppressor
Current Opinion in Cell Biology
Ashok R Venkitaraman
Abstract
The BRCA2 tumour suppressor works in DNA recombination and repair pathways to preserve genome integrity. Recent progress provides fresh insights into its role as a regulator of the Rad51 recombination protein, underpinning a model in which BRCA2's involvement in chromosome stability and tumour suppression arises from its participation in recombinational processes essential for DNA replication.
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