PMID: 6972087Mar 1, 1981Paper

Chromosome studies in acute lymphoblastic leukaemia (ALL)

Scandinavian Journal of Haematology
G H BorgströmA de la Chapelle

Abstract

Chromosome banding studies of the bone marrow were performed in 35 adult (greater than 14 years) patients with acute lymphoblastic leukaemia (ALL). Surface marker analysis was done in 24 of these and revealed 4 B-ALL, 5 T-ALL and 15 non-T non-B ALL. Most patients were studied at diagnosis before any treatment. A clonal karyotypic abnormality was found in 16 patients (46 %) initially. A Philadelphia chromosome was found in 3 patients, all belonging to the non-T non-B group. 5 patients, who all had blast cells with morphologic characteristics of Burkitt type L, were found to have bone marrow cells with a 14q + marker chromosome. In at least 4 cases this was due to a t(8;14). The cytogenetic findings showed some correlation to the ALL subgroup, but not to the response to treatment or the prognosis.

References

Jul 15, 1979·International Journal of Cancer. Journal International Du Cancer·F MitelmanP G Nilsson
Sep 1, 1979·British Journal of Haematology·R BergerG Flandrin
Jan 1, 1979·Human Genetics·E L PrigoginaI S Peterson
Jan 1, 1979·Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progrès Dans Les Recherches Sur Le Cancer·J V Simone
Nov 1, 1975·Scandinavian Journal of Haematology·S D LawlerR M Hardisty
Mar 1, 1980·British Journal of Haematology·J D Rowley

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