PMID: 1203847Jul 1, 1975Paper

Chromosomes and causation of human cancer and leukemia. XII. Banding analysis of abnormal chromosomes in polycythemia vera

Cancer
Y ShiraishiA A Sandberg

Abstract

The chromosome constitution of bone marrow cells was determined in 13 patients with polycythemia vera (PV). In 5 of these patients definite karyotypic abnormalities were found: 3 with 46,XY,Fq-; 1 with 46,XY,11q-, 13q-; and 1 with missing Y. The latter cytogenetic finding is thought not to be related to the PV. The 4 patients with partial deletions of chromosomes had been treated with 32P, and 3 of them with chemotherapy also. Karyotypes from 2 of these patients, 1 with 46,XY,20q-, and another with 46,XY,11q-,13q- were examined with G and/or Q banding. From the results of the banding analysis, it appears that the abnormal chromosomes were due to simple deletions at specific sites on their arms, particularly in the cases with the F abnormality (20q11). The breaks occurred in the regions C11q and D12q. The portions missing from the original chromosomes could not be found on any chromosome. Most patients with PV do not develop chromosomal abnormalities through the course of their disease; when such abnormalities appear (20q- in particular), they seem to result exclusively from radiation (and possibly chemo-) therapy. Thus, cytogenetic changes do not appear to play a crucial role in the genesis of PV.

References

Oct 30, 1971·Lancet·M Seabright
Jan 1, 1970·Chromosoma·T CasperssonE J Modest
Feb 1, 1974·Journal of the National Cancer Institute·J D Rowley
Jun 1, 1970·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S D LawlerH E Kay
Apr 1, 1968·British Journal of Haematology·R E MillardC B Cameron
Sep 1, 1966·British Journal of Haematology·H E KayR E Millard

❮ Previous
Next ❯

Citations

Mar 12, 1979·Human Genetics·L FindleyA Robinson
Jan 1, 1979·Human Genetics·E W FleischmanO E Kulagina
Jan 1, 1981·Cancer Genetics and Cytogenetics·H Zankl, K D Zang
May 1, 1984·Cancer Genetics and Cytogenetics·M P DavisH C Hoagland
Jul 1, 1984·Cancer Genetics and Cytogenetics·R BergerY Najean
Jan 1, 1984·Cancer Genetics and Cytogenetics·E Schmid, J Köhler
Nov 1, 1985·Cancer Genetics and Cytogenetics·D D JohnsonM N Silverstein
Apr 1, 1987·Cancer Genetics and Cytogenetics·G Rege-CambrinH Van den Berghe
Jul 1, 1976·Journal of Clinical Pathology·S D Lawler, B R Reeves
Jun 3, 2004·Cancer Genetics and Cytogenetics·Lurdes ZamoraFrancesc Solé
Jan 20, 2000·Baillière's Clinical Haematology·A J BenchA R Green
Jan 1, 1981·American Journal of Hematology·J R TestaJ W Vardiman
Oct 1, 1975·CRC Critical Reviews in Clinical Laboratory Sciences·L F Meisner
Sep 1, 1976·Scandinavian Journal of Haematology·J WestinB Swolin
Sep 1, 1976·Scandinavian Journal of Haematology·J Westin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
S D LawlerH E Kay
© 2022 Meta ULC. All rights reserved