Chromosomes and causation of human cancer and leukemia. XXIII. Near-haploidy in acute leukemia
A case of acute lymphoblastic leukemia (ALL) with a near-haploid (27 chromosomes) leukemic cell population in the marrow has been described and the findings compared to those of the only other such case in the literature. In both cases the cells with 27 chromosomes, except for one chromosomal group, had karyotypic findings which were identical. Cells with 54 chromosomes, karyotypically exact duplicates of the cells with 27 chromosomes, were also encountered; on morphological basis it appeared that the marrow contained large and small lymphoblasts, possibly matching the metaphases with 54 and 27 chromosomes, respectively. The genesis of the cells with 27 chromosomes was uncertain and several postulates are discussed, as well as the relation of the findings to the cytogenetic observations encountered in ALL and their possible role in human leukemogenesis.
Receptors for sheep erythrocytes (E) and erythrocyte-antibody-complement complexes (EAC) on the lymphoblasts of childhood acute lymphocyblastic leukemia
Studies of multipolar mitoses in euploid tissue cultures. I. Somatic reduction to exactly haploid and triploid chromosome sets
Pattern of DNA segregation in multipolar anatelophases of different ploidy in euploid and aneuploid mammalian cells cultivated in vitro
Cytogenetic analysis and flow cytometric DNA measurement of a human tumor with pronounced hypodiploidy
Studies of banded chromosomes in patients with acute lymphocytic leukemia, including one patient with the Burkitt-type (L3)
Chromosomes and causation of human cancer and leukemia. XLVII. severe hypodiploidy and chromosome conglomerations in ALL
Near-haploid cell line in the blastic crisis of chronic myelogenous leukemia: a possible marker for lymphoid malignancy
Ph-positive chronic myeloid leukemia with near-haploid conversion in vivo and establishment of a continuously growing cell line with similar cytogenetic pattern
Near haploid childhood acute lymphoblastic leukemia masked by hyperdiploid line: detection by fluorescence in situ hybridization
A near-haploid bone marrow karyotype in systemic mast cell disease: is it characteristic of the disease or an incidental finding?
Comparative analysis of G-banding, chromosome painting, locus-specific fluorescence in situ hybridization, and comparative genomic hybridization in chronic myeloid leukemia blast crisis
Near-haploid common acute lymphoblastic leukaemia of childhood with a second hyperdiploid line: a DNA ploidy and fluorescence in-situ hybridization study
24-36-Chromosome clones in human malignancies. Cytogenetic interrelationships, clinical significance and patient age
Adult acute lymphoblastic leukemia with near haploidy, hyperdiploidy and Ph positive lines: a rare entity with poor prognosis
Reassessment of the prognostic significance of hypodiploidy in pediatric patients with acute lymphoblastic leukemia
Next-generation-sequencing-based risk stratification and identification of new genes involved in structural and sequence variations in near haploid lymphoblastic leukemia
Near-haploidy and subsequent polyploidization characterize the progression of peripheral chondrosarcoma
Near-haploid and low-hypodiploid acute lymphoblastic leukemia: two distinct subtypes with consistently poor prognosis.
Chromosomes and causation of human cancer and leukemia. XXVI. Binding studies in acute lymphoblastic leukemia (ALL)
Chromosomes and causation of human cancer and leukemia: XXXIX. Usual and unusual findings in Ph1-positive CML
Blood And Marrow Transplantation
The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.