PMID: 6932994Nov 15, 1980

Chromosomes and causation of human cancer and leukemia: XXXIX. Usual and unusual findings in Ph1-positive CML

Cancer
S Kohno, A A Sandberg

Abstract

The chromosomal changes in the leukemic cells of 48 patients with Ph1-positive CML are reported. The karyotypic findings in the chronic phase (CP) and blastic phase (BP) were similar to those reported in the past, with +8, and extra Ph1, and an iso (17q) being the most common anomalies observed in BP. Unusual cytogenetic findings were observed in one patient whose cells (from lymph nodes, bone marrow, and blood) were characterized by very marked hypodiploidy and hypo-haploidy, with some of the cells having less than 20 chromosomes. In each of these very hypodiploid metaphases, conglomerations of darkly stained and condensed chromosomes were seen. These conglomerations consisted of a few to eight chromosomes. The role played by these chromosomes in the genesis of severe hypodiploidy is uncertain. The patient was thought to have "lymphoid" types of leukemic cells in BP, with an extramedullary origin of such cells, particularly in lymph nodes, playing a major role in the genesis of BP. The reported cases of near-haploidy with Ph1-positive CML and those with constitutional translocations with CML have been tabulated and the possible significance of the cytogenetic abnormalities discussed.

References

Jan 1, 1978·Medical and Pediatric Oncology·S Kohno, A A Sandberg
Jan 1, 1979·Leukemia Research·C Stoll, F Oberling
Jan 1, 1978·American Journal of Medical Genetics·V M RiccardiD Peakman
Jan 1, 1976·Acta Haematologica·J Whang-PengR C Young
Apr 1, 1976·The Journal of Pediatrics·D Warburton, N Shah
Jul 7, 1971·Nature: New Biology·A T SumnerR A Buckland
Oct 30, 1971·Lancet·M Seabright
Jan 1, 1974·Scandinavian Journal of Haematology·O M Garson, W J Milligan
Sep 30, 1965·The New England Journal of Medicine·E EngelM Engel-de Montmollin
Jun 1, 1971·Journal of Medical Genetics·B Dallapiccola, P Malacarne
Jan 15, 1980·Cancer·K O GohP L Townes

Citations

Mar 1, 1979·[Rinshō ketsueki] The Japanese journal of clinical hematology·K Ota
Dec 1, 1982·Cancer Genetics and Cytogenetics·F CarbonellJ Sánchez-Fayos
Jan 1, 1984·Cancer Genetics and Cytogenetics·Y S LiF G Hayhoe
Jan 1, 1985·Cancer Genetics and Cytogenetics·S ChemitigantiH Dosik
Feb 15, 1986·Cancer Genetics and Cytogenetics·S L KermanD W Heritage
Nov 1, 1987·Cancer Genetics and Cytogenetics·G C AvanziL Pegoraro
Feb 1, 1989·Cancer Genetics and Cytogenetics·M De Braekeleer, M Vekemans
Jul 15, 1990·Cancer Genetics and Cytogenetics·F Hild, C Fonatsch
Jan 1, 1987·Leukemia Research·R S Verma, M J Macera
Feb 1, 1987·Journal of Medical Genetics·J C KaplanM F Szajnert
Sep 1, 1982·Jinrui idengaku zasshi. The Japanese journal of human genetics·T TomiyasuM Okada

Related Concepts

Autosome Abnormalities
Chromosomes, Human,21-22
Karyotype Determination Procedure
Leukemia, Monocytic, Chronic

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