Abstract
Cytogenetic and immunologic studies were performed on the cells of an 18-year-old female with ataxia telangiectasia (AT) associated with acute lymphocytic leukemia (ALL). At the onset of the leukemia 15.4% of peripheral blood cells stimulated with phytohemagglutinin (PHA) contained a tandem translocation of the long arm of chromosome #14, i.e., t(14;14). To ascertain if these karyotypically abnormal cells and the leukemic cells had a common lineage, chromosome analyses were performed on bone marrow cells. Examination of the marrow cells on the seven occasions when leukemic cells were present in the marrow, including times when they were predominant, showed only a normal karyotype without the presence of t(14;14). However, an abnormal clone, which had the karyotype 45,XX,-9,t(9;6)(q12;q13), was identified in the marrow cells on the last examination during the terminal phase of the leukemia. Immunologically, the ALL was classified as an atypical type which had characteristics in common with certain T-cell subsets. We suggest that the malignant cells did not originate from the preexisting cells with a tandem duplication of the 14q.
References
Mar 29, 1979·The New England Journal of Medicine·A SaxonD W Golde
Jun 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·B K McCawR L Teplitz
Oct 1, 1992·Leukemia & Lymphoma·D HaaseM Freund
Aug 9, 1973·The New England Journal of Medicine·F HechtR D Koler
Feb 1, 1981·The Journal of Experimental Medicine·J A LedbetterL A Herzenberg
May 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·I S Trowbridge, M B Omary
Apr 1, 1980·Cancer·S R Toledano, B J Lange
Mar 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·E L ReinherzS F Schlossman
Apr 1, 1980·Cell·E L Reinherz, S F Schlossman
Jan 1, 1980·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·P NemetM Lazar
Aug 1, 1981·Cancer Genetics and Cytogenetics·R BernsteinT Jenkins
Jan 1, 1981·Human Genetics·P C Huang, R B Sheridan
Feb 1, 1964·Journal of Neurology, Neurosurgery, and Psychiatry·H L UTIAN, M PLIT
Citations
Jan 1, 1984·Human Genetics·C WallaceM R Pinto
Jul 1, 1984·Cancer Genetics and Cytogenetics·F Hecht, B K Hecht
Jun 1, 1987·Cancer Genetics and Cytogenetics·R Becher, C Dührsen
Jan 1, 1988·Cancer Genetics and Cytogenetics·C MecucciH Van Den Berghe
Jun 1, 1992·Cancer Genetics and Cytogenetics·I PetkovićM Nakić
Mar 1, 1985·Cancer Treatment Reviews·J Pedersen-Bjergaard
Jun 6, 1998·Cancer Genetics and Cytogenetics·S H MaljaeiD Catovsky
Nov 30, 1985·Lancet·L HendersonS Meller
Oct 15, 1991·Cancer Genetics and Cytogenetics·T L KojisR S Sparkes
Aug 30, 1988·Biochemical and Biophysical Research Communications·K TakedaK Konno
Sep 14, 1999·Pathology, Research and Practice·R S Neiman, A Orazi
Oct 1, 1988·Journal of Surgical Oncology·C MockJ P Crowley
Feb 1, 1993·Journal of Medical Genetics·D HernandezA M Taylor
Feb 1, 1994·Archives of Disease in Childhood·G M Taylor
Jan 1, 1988·Medical Oncology and Tumor Pharmacotherapy·H G Ahuja, M J Cline
Oct 10, 1986·Science·C T DennyI R Kirsch