PMID: 6981453Aug 1, 1982Paper

Chromosomes and causation of human cancer and leukemia. XLVIII. T-cell acute leukemia in ataxia telangiectasia

Cancer Genetics and Cytogenetics
N WakeA A Sandberg

Abstract

Cytogenetic and immunologic studies were performed on the cells of an 18-year-old female with ataxia telangiectasia (AT) associated with acute lymphocytic leukemia (ALL). At the onset of the leukemia 15.4% of peripheral blood cells stimulated with phytohemagglutinin (PHA) contained a tandem translocation of the long arm of chromosome #14, i.e., t(14;14). To ascertain if these karyotypically abnormal cells and the leukemic cells had a common lineage, chromosome analyses were performed on bone marrow cells. Examination of the marrow cells on the seven occasions when leukemic cells were present in the marrow, including times when they were predominant, showed only a normal karyotype without the presence of t(14;14). However, an abnormal clone, which had the karyotype 45,XX,-9,t(9;6)(q12;q13), was identified in the marrow cells on the last examination during the terminal phase of the leukemia. Immunologically, the ALL was classified as an atypical type which had characteristics in common with certain T-cell subsets. We suggest that the malignant cells did not originate from the preexisting cells with a tandem duplication of the 14q.

References

Mar 29, 1979·The New England Journal of Medicine·A SaxonD W Golde
Jun 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·B K McCawR L Teplitz
Aug 9, 1973·The New England Journal of Medicine·F HechtR D Koler
May 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·I S Trowbridge, M B Omary
Apr 1, 1980·Cancer·S R Toledano, B J Lange
Mar 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·E L ReinherzS F Schlossman
Apr 1, 1980·Cell·E L Reinherz, S F Schlossman
Jan 1, 1980·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·P NemetM Lazar
Aug 1, 1981·Cancer Genetics and Cytogenetics·R BernsteinT Jenkins
Jan 1, 1981·Human Genetics·P C Huang, R B Sheridan
Feb 1, 1964·Journal of Neurology, Neurosurgery, and Psychiatry·H L UTIAN, M PLIT

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Citations

Jul 1, 1984·Cancer Genetics and Cytogenetics·F Hecht, B K Hecht
Jun 1, 1987·Cancer Genetics and Cytogenetics·R Becher, C Dührsen
Jan 1, 1988·Cancer Genetics and Cytogenetics·C MecucciH Van Den Berghe
Jun 1, 1992·Cancer Genetics and Cytogenetics·I PetkovićM Nakić
Oct 15, 1991·Cancer Genetics and Cytogenetics·T L KojisR S Sparkes
Sep 14, 1999·Pathology, Research and Practice·R S Neiman, A Orazi
Oct 1, 1988·Journal of Surgical Oncology·C MockJ P Crowley
Feb 1, 1994·Archives of Disease in Childhood·G M Taylor
Jan 1, 1988·Medical Oncology and Tumor Pharmacotherapy·H G Ahuja, M J Cline

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