PMID: 6985828Jan 1, 1980Paper

Chromosomes and causation of human cancer and leukemia. XXXV. The missing Y in acute non-lymphocytic leukemia (ANLL)

Cancer
S AbeA A Sandberg

Abstract

The bone marrow chromosomes in six ANLL patients with a missing Y were examined. In all of six cases, the missing Y was the only chromosomal abnormality at diagnosis, and it persisted through their clinical courses. One patient had a shift from the 45,X to a 47,XX, +5, 13q + karyotype in the terminal phase of the disease. The findings indicate that the 45,X cells were not involved in further karyotypic progression, and that the leukemic process usually seemed to involve the 46,XY cell rather than the 45,X cells. Based on the data of the current study and that in the literature, it appears that the presence of missing Y in ANLL may afford a rather benign clinical course to such patients when compared to that of the ANLL patients with a missing Y. It is suggested that the age of the patients, karyotypic differences and degree of a missing Y in the marrow cells may affect the clinical course of ANLL.

References

Jan 25, 1975·Lancet·H ZanklK D Zang
Jan 1, 1979·British Journal of Haematology·T Padre-MendozaE N Forman
Jul 15, 1976·International Journal of Cancer. Journal International Du Cancer·F MitelmanL Brandt
Feb 17, 1973·Lancet·A A Sandberg, M Sakurai
Jan 1, 1974·Acta Haematologica·D K Hossfeld, E Wendehorst
Oct 1, 1972·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M Sellyei, L Vass
Oct 1, 1971·British Journal of Haematology·L M Walker
Jul 1, 1970·British Journal of Haematology·M L O'RiordanI M Tough

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Citations

May 1, 1993·American Journal of Hematology·I AurerR P Gale
Aug 1, 1993·Journal of Surgical Oncology·Y M ShyrW Y Lui
Jan 1, 1985·Cancer Metastasis Reviews·R J BernackiW Korytnyk
Jan 1, 1984·Cancer Metastasis Reviews·L Larizza, V Schirrmacher
Jan 1, 1983·Cancer Metastasis Reviews·S R Wolman
Jan 1, 1983·Cancer Metastasis Reviews·L Olsson
Jul 1, 1986·Clinical & Experimental Metastasis·S L AukermanI J Fidler
Jan 1, 1987·Journal of Neuro-oncology·F R LatimerT O Robbins
Jan 1, 1983·Human Genetics·G P PuchkovaI S Peterson
Apr 1, 1986·Human Genetics·M M Le BeauJ D Rowley
Jan 1, 1984·Human Genetics·P H Fitzgerald, C M Morris
Jan 1, 1982·Blut·S J Muts-HomsmaJ P Geraedst
Jan 1, 1987·Chromosoma·R K MoyzisT Schwarzacher-Robinson
Jan 1, 1991·Neurosurgical Review·J M ValduezaH D Herrmann
Jan 1, 1986·Journal of Cancer Research and Clinical Oncology·F FrankeF Lampert
Jul 1, 1986·Human Genetics·R MorganA A Sandberg
Jan 1, 1987·Archives of Dermatological Research·K KaltoftW Sterry
Jan 1, 1984·European Journal of Pediatrics·C R Bartram
Jan 1, 1995·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·J J Boei, A T Natarajan
Jan 1, 1984·Journal of Cancer Research and Clinical Oncology·P Tautu, G Wagner
Nov 1, 1981·Somatic Cell Genetics·A H Geurts van KesselA Hagemeijer
Jan 1, 1990·Journal of Cancer Research and Clinical Oncology·W HiddemannT Büchner
Jul 1, 1988·Clinical & Experimental Metastasis·J P Volpe, L Milas
Jan 1, 1985·Breast Cancer Research and Treatment·J M Trent
Jan 1, 1981·Breast Cancer Research and Treatment·T R Chen, G Seman
Jan 1, 1986·Breast Cancer Research and Treatment·E GebhartW Schmidt
Feb 1, 1986·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·K H Walen, P Arnstein
Feb 1, 1994·In Vitro Cellular & Developmental Biology. Animal·S RauthT K Das Gupta
Nov 1, 1989·Indian Journal of Pediatrics·R AbeS Kariyone
Sep 1, 1984·Indian Journal of Pediatrics·R P WarrierS Kottamasu
May 1, 1992·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·E Hellmén

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