PMID: 6967231Mar 1, 1980Paper

Chromosomes in tumors derived from mouse tumor x diploid cell hybrids obtained in vitro

Somatic Cell Genetics
D AvilèsJ Jami

Abstract

Hybrids formed in vivo between Cl.1D tumor cells and host cells have been shown to carry a copy of each chromosome pair contributed by the host cell parent (1). However, in these hybrids, the tissue type of the host cell parents remained unknown. In the present study, hybrids between the malignant Cl.1D fibroblasts and either normal diploid fibroblasts (CF hybrids) or normal thymocytes (CT hybrids) were examined. These hybrids produced tumors when injected into host mice. Metaphases of growing hybrid cell tumors were analyzed. Neither CF nor CT malignant hybrids showed loss of any specific chromosome pair contributed by the normal cell parent. Since elimination of any chromosome pair contributed by the diploid fibroblast parent is not a prerequisite for CF hybrid tumoral growth, it seems unlikely that malignancy of hybrids results from nonexpression of normal alleles of those genes putatively implied in malignancy of Cl.1D cells.

References

Jun 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·J Jami, E Ritz
Sep 1, 1976·Cell·R A Miller, F H Ruddle
Sep 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·B Mintz, K Illmensee
Jan 1, 1976·Journal of Cellular Physiology·N Bloch-Shtacher, L Sachs
Mar 4, 1976·Nature·E J Stanbridge
Oct 30, 1971·Lancet·M Seabright
Jul 26, 1969·Nature·H HarrisT Tachibana
Mar 1, 1958·Stain Technology·K H ROTHFELS, L SIMINOVITCH

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Citations

Dec 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·D S Roos, P W Choppin
Nov 1, 1981·Somatic Cell Genetics·A H Geurts van KesselA Hagemeijer
May 15, 1984·International Journal of Cancer. Journal International Du Cancer·J K Cowell, L M Franks
Feb 1, 1982·Molecular and Cellular Biology·N Bouck, G di Mayorca

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