Chronic (3-Weeks) Treatment of Estrogen (17β-Estradiol) Enhances Working and Reference Memory in Ovariectomized Rats: Role of Acetylcholine

Neurochemical Research
Gülay UzümY Zíya Zíylan

Abstract

Recently there has been a growing interest in the effects of estrogen on cognitive functions. In this study, we aimed to examine 17β-estradiol treatment on working and reference memory in ovariectomized rats. We also examined the changes in the acetylcholine (ACh) levels in the brain areas associated with learning and memory. The study was performed on Sprague-Dawley type 3-month-old female rats. The rats were divided into four groups as control, ovariectomy (OVX), and OVX and estrogen treatment (10 µg/day i.p. 17β-estradiol) groups for 3 (OVX + E3) and 21 days OVX + E21). The rats were trained on eight arm radial maze task with eight arms baited to assess spatial memory, in addition four arms baited to assess both working and reference memory performances. The electron microscope images of the ACh vesicles in the frontal cortex, temporal cortex and hippocampus areas of the brain which are important regions for learning and memory were screened. Results showed that long term 17β-estradiol treatment has positive effects on both reference memory and working memory and that ACh vesicles increased in the examined brain areas, especially in hippocampus. Our results suggest that 3 weeks 17β-estradiol treatment may have an ameliorativ...Continue Reading

References

Sep 1, 1988·Neurobiology of Aging·C A Barnes
May 1, 1983·The International Journal of Neuroscience·B S Chozick
Feb 10, 1998·Hormones and Behavior·J M DanielG P Dohanich
Feb 28, 2002·Hormones and Behavior·Taneli HeikkinenHeikki Tanila
Jun 18, 2003·Neuroscience·A V Savonenko, A L Markowska
Jun 26, 2004·Annual Review of Neuroscience·Larry R SquireRobert E Clark
Sep 17, 2004·The International Journal of Neuroscience·Gülay UzümY Zíya Zíylan
Oct 21, 2004·The Journal of the British Menopause Society·Robert KingSoo Keat Khoo
Aug 2, 2005·Neurobiology of Learning and Memory·D M DavisS J Y Mizumori
Sep 22, 2005·Clinical and Experimental Pharmacology & Physiology·Kazuaki ShinomiyaChiaki Kamei
Nov 4, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Morgan D BarenseKim S Graham
Dec 19, 2006·Hormones and Behavior·Ray NorburyDeclan G M Murphy
Jun 3, 2008·Journal of Neuroendocrinology·V N Luine
Apr 27, 2010·Behavioural Brain Research·Assunta PompiliAntonella Gasbarri
Jul 8, 2010·Computers in Biology and Medicine·Hakan IşikMustafa Cihat Avunduk
Sep 11, 2010·Neurobiology of Learning and Memory·Luis F JacomeVictoria Luine
Sep 25, 2012·The International Journal of Neuropsychopharmacology·Na QuQi Zhang
Jan 10, 2014·The Journal of Endocrinology·Lydie NauléSakina Mhaouty-Kodja
Jun 26, 2015·Physiological Reviews·Yuko HaraJohn H Morrison

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Forebrain- Circuits

Basal forebrain is a region in the brain important for production of acetylcholine and is the major cholinergic output of the CNS. Discover the latest research on circuits in the basal forebrain here.