Chronic acamprosate eliminates the alcohol deprivation effect while having limited effects on baseline responding for ethanol in rats

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
C J HeyserG F Koob

Abstract

Acamprosate (calcium-acetyl homotaurinate) is a relatively new compound developed for the treatment of alcoholism and has been shown to be effective in attenuating relapse in human alcoholics. In the current study, the effects of this drug were further examined using an animal model of oral ethanol self-administration in a limited access paradigm. Male Wistar rats were trained to respond for ethanol (10% w/v) or water in a two-lever free-choice operant condition. Acute administration of acamprosate (400 mg/kg) reduced ethanol consumption and increased responding for water. Chronic administration of lower daily doses of acamprosate (100 and 200 mg/kg) blocked the increased ethanol consumption typically observed in rats after an imposed abstinence period. This effect of acamprosate was selective for ethanol, as responding for water was unaffected at any dose tested. These results with rats suggest a model by which to explore the mechanisms for anti-relapse effects of acamprosate.

Citations

Sep 8, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·W H SommerM Heilig
May 2, 2003·Psychopharmacology·David H Epstein, Kenzie L Preston
Mar 15, 2005·Psychopharmacology·George R BreeseDarin J Knapp
Jun 24, 2003·Physiology & Behavior·Todd E Thiele, Nancy E Badia-Elder
Jun 6, 2000·Pharmacology, Biochemistry, and Behavior·S M HölterR Spanagel
Nov 5, 1999·Pharmacology, Biochemistry, and Behavior·M F StrombergS A Mackler
Aug 23, 2002·Pharmacology & Therapeutics·A Lê, Y Shaham
Apr 12, 2003·Drug and Alcohol Dependence·Giancarlo ColomboGian Luigi Gessa
Sep 16, 1998·Current Opinion in Chemical Biology·L Terenius
Jun 28, 2003·Best Practice & Research. Clinical Gastroenterology·Rainer Spanagel
Mar 5, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jeffrey A SimmsSelena E Bartlett
Jul 29, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Verginia C Cuzon CarlsonKathleen A Grant
Jan 26, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Daniel BachtelerRainer Spanagel
Aug 18, 2006·Behavioural Pharmacology·Andrew J Mcgeehan, Michael Foster Olive
Sep 1, 2007·Journal of Addiction Medicine·John M Littleton
Jun 9, 2006·Addiction Biology·Tobie Escher, Guy Mittleman
Sep 14, 2007·Addiction Biology·Roberto RimondiniMarkus Heilig
Dec 18, 2003·Psychiatry and Clinical Neurosciences·Sung-Gon KimMichael F Stromberg
Oct 8, 1999·Alcoholism, Clinical and Experimental Research·C J HeyserG F Koob
Feb 3, 2000·Alcoholism, Clinical and Experimental Research·Z A Rodd-HenricksT K Li
Nov 15, 2001·Alcoholism, Clinical and Experimental Research·A D LêS Harding
Mar 10, 2001·Alcoholism, Clinical and Experimental Research·B A FlanneryD J Rohsenow
Apr 6, 2001·Alcoholism, Clinical and Experimental Research·C L CzachowskiH H Samson
Jun 8, 2001·Alcoholism, Clinical and Experimental Research·T K LiZ A Rodd-Henricks
Apr 20, 2002·Alcoholism, Clinical and Experimental Research·W J McBrideA Noronha
Dec 1, 2006·Neuropsychiatric Disease and Treatment·Tara M Wright, Hugh Myrick
Sep 17, 2005·Nursing Times
Jan 1, 2007·Indian Journal of Psychiatry·Sandeep GroverDebasish Basu
Oct 2, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Rainer SpanagelFalk Kiefer
Jun 22, 2010·Expert Opinion on Emerging Drugs·Michael Soyka, Susanne Rösner

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