Chronic activation of dopamine receptors in the female infantile rat: effect on hypophyseal hormones and on the onset of puberty

Endocrinology
I M de MengidoC Libertun

Abstract

In the female rat the period from days 7-20 of age is special with regard to regulation of hypophyseal hormone secretion. This period is characterized by high FSH levels and the occurrence of sporadic LH peaks. As it has been reported that haloperidol could enhance both gonadotropins at 12 days of age and not at later ages, it was of interest to treat rats during the infantile period with pergolide, a dopaminergic agent of long action, and evaluate its effect on hormone levels and puberty onset. Three different schedules of drug injections were applied: 1) daily injections (0.05 mg/kg.day) on days 1-10, 2) daily injections on days 5-14, and 3) daily injections on days 11-20. It was found that only animals treated with daily injections of pergolide on days 11-20 showed an advance in the age of vaginal opening and first estrus compared to distilled water-injected controls. Thus, the rest of the experiments were performed using injection schedule 3. In this group of animals serum LH and FSH levels were decreased 3 and 6 days after the beginning of pergolide treatment (13 and 16 days of age); at 19 days of age pergolide did not modify gonadotropin levels. One day after the end of pergolide treatment (day 21 of age), there was a reb...Continue Reading

Citations

Feb 1, 1992·Cellular and Molecular Neurobiology·D Becú-VillalobosC Libertun
Dec 1, 1990·Cellular and Molecular Neurobiology·D Becú-VillalobosC Libertun
Feb 1, 1995·Cellular and Molecular Neurobiology·D Becú-Villalobos, C Libertun
Nov 20, 1992·Brain Research. Developmental Brain Research·G Díaz-TorgaC Libertun
May 19, 2000·Neuroscience and Biobehavioral Reviews·L P Spear
Dec 3, 2015·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Lorraine M PosobiecTimothy Hart
Feb 13, 2001·Endocrine Reviews·E Terasawa, D L Fernandez
Feb 1, 1994·The American Journal of Physiology·D Becú-VillalobosC Libertun

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