Chronic administration of antioxidant resin from Virola oleifera attenuates atherogenesis in LDLr -/- mice

Journal of Ethnopharmacology
Paola Nogueira CoutinhoThiago Melo Costa Pereira

Abstract

Virola oleifera (Schott) A. C. Smith, Myristicaceae has been largely used in traditional folk medicine in Brazil as an anti-inflammatory agent and our previous data indicated the antioxidant properties in other oxidative stress-related models. However, its effects on atherosclerosis (AT) are not yet investigated. To evaluate the influence of resin from Virola oleifera (RV) on progression of AT in LDLr-/- mice. LDLr-/- mice were divided into 4 groups: 1) The ND group received a normal diet without treatment. 2) The HD group received a high-fat diet without treatment. 3) The HD-V50 received a high-fat diet and was orally treated with RV at 50mg/Kg. 4) The HD-V300 received a high-fat diet and was orally treated with RV at 300mg/Kg. After 4 weeks, blood was collected to quantify biochemical parameters and ROS total and the aorta was removed to measure the lipid deposition by en face analysis. The liver was also collected to determine total lipids and lipid and protein oxidation. In order to investigate in more detail the contributions of RV in the vascular structure, we carried out the in vitro tests using four cellular types: macrophages, fibroblasts, vascular smooth muscle and endothelial cells. We showed that the chronic treatme...Continue Reading

References

Jan 8, 2013·Journal of Translational Medicine·Camille M BalariniElisardo C Vasquez

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Citations

Jul 10, 2019·Oxidative Medicine and Cellular Longevity·Layla Aparecida ChistéThiago Melo Costa Pereira
Feb 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·María González-RodríguezOreste Gualillo

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