Chronic Administration of Catestatin Improves Autonomic Function and Exerts Cardioprotective Effects in Myocardial Infarction Rats

Journal of Cardiovascular Pharmacology and Therapeutics
Dandan WangCongxin Huang

Abstract

Catestatin (CST), which is emerging as a novel cardiac modulator, can protect the heart against excessive sympathetic drive in hypertensive cardiomyopathy. The aim of this study is to investigate whether exogenous CST decreases excessive cardiac sympathetic drive and improves autonomic function and exerts cardioprotective effects in myocardial infarction (MI) rats. Rats were divided into a sham group, MI group, and MI plus CST (MI + CST) group. Four weeks later, the autonomic function of the animals was assessed by analyzing heart rate variability (HRV) and measuring plasma catecholamine. Cardiac function was evaluated via echocardiography. Electrophysiological characteristics were assessed in Langendorff-perfused hearts. Compared to the MI group, the chronic administration of CST significantly increased the standard deviation of normal-normal intervals (P < .01) and low-frequency (LF) and high-frequency (HF) HRV and decreased the ratio of LF-HF HRV (P < .01 for all). Additionally, the level of plasma catecholamine was reduced in the MI + CST group compared to the MI group (P < .01). Treatment with CST significantly increased ejection fraction (EF) and fraction shorting (FS) and significantly decreased the left ventricular end-...Continue Reading

References

Aug 1, 1992·Neuroscience·H Winkler, R Fischer-Colbrie
Mar 24, 2004·Hypertension·Jens TankJens Jordan
Apr 17, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Wen DunPenelope A Boyden
Jul 12, 2005·The Journal of Clinical Investigation·Nitish R MahapatraSushil K Mahata
May 13, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Rosa MazzaSushil K Mahata
Sep 5, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Arun SridharCynthia A Carnes
Feb 4, 2009·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Lance D WilsonDavid S Rosenbaum
Aug 18, 2009·American Journal of Physiology. Heart and Circulatory Physiology·George E Billman
Sep 30, 2009·Brain Research·Andrea H GaedePaul M Pilowsky
Feb 2, 2010·Regulatory Peptides·Sushil K MahataDaniel T O'Connor
Jul 29, 2010·Clinical and Experimental Hypertension : CHE·Maple M FungDaniel T O'Connor
Aug 25, 2011·Endocrine Reviews·Alessandro BartolomucciStephen R J Salton
Dec 12, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Marcus HenzeKarie Scrogin
May 22, 2013·Scandinavian Cardiovascular Journal : SCJ·Lin LiuChaoshu Tang
Nov 13, 2013·Progress in Cardiovascular Diseases·Heikki V Huikuri, Phyllis K Stein

❮ Previous
Next ❯

Citations

Dec 25, 2016·Human Molecular Genetics·Beben BenyaminDaniel T O'Connor
Jan 18, 2017·Cellular and Molecular Life Sciences : CMLS·Alexander WidiapradjaScott P Levick
Aug 2, 2019·Journal of Clinical Medicine·Josip A BorovacJosko Bozic
Oct 12, 2017·Pflügers Archiv : European journal of physiology·Angelo CortiTiziana Bachetti

❮ Previous
Next ❯

Software Mentioned

Empower
SPSS
Chart

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Acute viral rhinopharyngitis

Acute viral rhinopharyngitis, also known as "common cold", is an acute, self-limiting viral infection of the upper respiratory tract involving the nose, sinuses, pharynx and larynx. Discover the latest research on acute viral rhinopharyngitis here.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.