Chronic administration of resveratrol prevents morphological changes in prefrontal cortex and hippocampus of aged rats

Synapse
Elizabeth Monserrat Hernández-HernándezGonzalo Flores

Abstract

Resveratrol may induce its neuroprotective effects by reducing oxidative damage and chronic inflammation apart from improving vascular function and activating longevity genes, it also has the ability to promote the activity of neurotrophic factors. Morphological changes in dendrites of the pyramidal neurons of the prefrontal cortex (PFC) and hippocampus have been reported in the brain of aging humans, or in humans with neurodegenerative diseases such as Alzheimer's disease. These changes are reflected particularly in the decrement of both the dendritic tree and spine density. Here we evaluated the effect of resveratrol on the dendrites of pyramidal neurons of the PFC (Layers 3 and 5), CA1- and CA3-dorsal hippocampus (DH) as well as CA1-ventral hippocampus, dentate gyrus (DG), and medium spiny neurons of the nucleus accumbens of aged rats. 18-month-old rats were administered resveratrol (20 mg/kg, orally) daily for 60 days. Dendritic morphology was studied by the Golgi-Cox stain procedure, followed by Sholl analysis on 20-month-old rats. In all resveratrol-treated rats, a significant increase in dendritic length and spine density in pyramidal neurons of the PFC, CA1, and CA3 of DH was observed. Interestingly, the enhancement in ...Continue Reading

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Citations

Apr 2, 2016·Oxidative Medicine and Cellular Longevity·K S Petersen, C Smith
Sep 16, 2016·Neural Regeneration Research·Gonzalo FloresAlfonso Diaz
Oct 19, 2017·Food & Function·Abdur RaufMohammad S Mubarak
Jan 8, 2019·Critical Reviews in Food Science and Nutrition·Danyue ZhaoQingli Wu
Mar 23, 2017·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Jessica StockingerGregorio Valdez
Sep 16, 2017·Journal of Food and Drug Analysis·Hui-Yun TsaiYu-Kuo Chen
Sep 19, 2019·Journal of Agricultural and Food Chemistry·Francesca CaracciGiulio Maria Pasinetti

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