Chronic administration of Satsuma mandarin fruit (Citrus unshiu Marc.) improves oxidative stress in streptozotocin-induced diabetic rat liver

Biological & Pharmaceutical Bulletin
Minoru SugiuraMasamichi Yano

Abstract

Fruits and vegetables contain numerous antioxidants such as carotenoids, vitamins, and phenolic phytochemicals. Recent studies have demonstrated that antioxidants may reduce the risk for diabetes or its complications. In this study, we investigated the effects of the chronic administration of Satsuma mandarin fruit on an antioxidant defense system in streptozotocin (STZ)-induced diabetic rat liver. After a ten-week administration of Satsuma mandarin, antioxidant enzymes and glutathione levels in the liver were evaluated. The superoxide dismutase (SOD), catalase, and glutathione-peroxidase (GPx) activities, and glutathione level in the STZ-induced diabetic rats liver decreased significantly compared with those in the age-matched normal rats. The glutathione-reductase (GR) activities did not differ significantly between these two groups. In contrast, the SOD, GR, and glutathione levels in the Satsuma mandarin (1% or 3%) diet-fed STZ-diabetic rat livers were significantly higher than those in the normal diet-fed STZ-diabetic rat livers. In addition, although the serum alanine aminotransferase and gamma-glutamyl-aminotransferase concentrations of normal diet-fed STZ-diabetic rats were significantly higher than those of the age-matc...Continue Reading

References

Aug 29, 1988·FEBS Letters·T Sakurai, S Tsuchiya
Nov 28, 1988·The American Journal of Medicine·W C DuckworthD E Peavy
Jun 24, 1998·Biochemical and Biophysical Research Communications·Y YamamotoT Yoshikawa
Nov 17, 1998·Diabetes/metabolism Reviews·M de Veciana
Sep 7, 1999·European Journal of Clinical Nutrition·M A AbahusainE B de Vol
Dec 20, 1999·Journal of Agricultural and Food Chemistry·S KawaiiM Yano
Jun 5, 2002·Journal of Hepatology·Sanjiv K JainThomas W Warnes
Oct 19, 2002·The American Journal of Gastroenterology·Dhiraj YadavC S Pitchumoni
Jan 30, 2004·Diabetes Care·Jukka MontonenAntti Reunanen
May 22, 2004·Public Health Nutrition·S A StannerJ Buttriss
Jul 12, 2005·Diabetes Research and Clinical Practice·Minoru SugiuraAkihiko Nagao

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Citations

Jan 1, 2011·Journal of Basic and Clinical Physiology and Pharmacology·Kalaivanan Kalpana, Kodukkur Viswanathan Pugalendi
Oct 25, 2008·Critical Reviews in Food Science and Nutrition·Gregory Tucker, Kevin Robards
Mar 26, 2008·Journal of Medicinal Food·Patrícia D S SpadaMirian Salvador
May 12, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Mediha SefiNajiba Zeghal
Jul 27, 2014·Asian Pacific Journal of Tropical Medicine·Ademola AyelesoOluwafemi Oguntibeju
Jun 24, 2017·Journal of Dietary Supplements·Mohabbulla MohibAbu Taher Sagor
Feb 6, 2020·Bioscience, Biotechnology, and Biochemistry·Atsushi ToyodaEiichi Inoue
Jul 26, 2011·International Journal of Biological Macromolecules·Imen DahechHafedh Mejdoub

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