PMID: 1383493Aug 1, 1992Paper

Chronic administration of the antidepressant-antipanic drug phenelzine and its N-acetylated analogue: effects on monoamine oxidase, biogenic amines, and alpha 2-adrenoreceptor function

Journal of Pharmaceutical Sciences
K F McKennaA J Greenshaw

Abstract

Phenelzine (PLZ), a nonselective monoamine oxidase inhibitor, is widely used in psychiatry for the treatment of panic disorder and depression. The effects of chronic (28-day) administration of PLZ (0.05 mmol/kg/day) and its N-acetylated analogue, 1-acetyl-2-(2-phenylethyl) hydrazine (N2-acetylphenelzine; N2AcPLZ; 0.10 mmol/kg/day), on alpha 2-adrenoreceptor function were investigated by use of a behavioral test on days 21 and 22. Rats treated with PLZ or N2AcPLZ displayed a significant attenuation of the suppressant effects of clonidine on spontaneous locomotor activity, compared with controls; these results suggest a reduced sensitivity of alpha 2-adrenoreceptors. By day 28, both PLZ and N2AcPLZ had produced greater than 85% inhibition of monoamine oxidases A and B in the brain, heart, and liver. Both drugs induced significant elevations of whole-brain levels of noradrenaline, 5-hydroxytryptamine, and dopamine, compared with those in controls. The levels of acid metabolites of dopamine and 5-hydroxytryptamine (homovanillic acid, 3,4-dihydroxyphenylacetic acid, and 5-hydroxyindole-3-acetic acid) were significantly reduced in both groups of drug-treated animals.

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Citations

Mar 5, 1999·Molecular Neurobiology·Cynthia L BetheaZ N Lu
Jun 8, 2002·Pharmacogenomics·Peter Meisel
Jul 5, 2019·The Journal of Pharmacology and Experimental Therapeutics·Josep MercaderChristian Carpéné
Sep 28, 2018·International Journal of Molecular Sciences·Christian CarpénéJosep Mercader
May 13, 1999·Cellular and Molecular Neurobiology·G B BakerS H Kennedy
Mar 22, 2002·Frontiers in Neuroendocrinology·Cynthia L BetheaJohn M Streicher

Related Concepts

N-acetylphenelzine
Thymoleptics
Biogenic Amines
Brain
Isoglaucon
Intropin
Homovanillic Acid
Hydroxyindoleacetic Acid
Alloenzymes
Monoamine Oxidase

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