Chronic administration of troxerutin protects mouse kidney against D-galactose-induced oxidative DNA damage

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Chan-Min LiuYao Lou

Abstract

Troxerutin, a natural bioflavonoid, has been reported to have many benefits and medicinal properties. In this study, we evaluated the protective effect of troxerutin against D-gal-induced oxidative DNA damage in mouse kidney, and explored the potential mechanism of its action. Our data showed that troxerutin significantly decreased levels of urea, uric acid and creatinine in serum and the renal histological injury in D-gal-treated mice. Troxerutin markedly restored Cu/Zn-SOD, CAT and GPx activities in the kidney of D-gal-treated mouse. Furthermore, the increase of 8-hydroxydeoxyguanosine (a marker of oxidative DNA damage) induced by d-gal was effectively suppressed by troxerutin. Internucleosomal DNA ladder fragmentation and the number of terminal deoxynucleotidyl transferase (TdT)-mediated deoxyuridine triphosphate (dUTP) nick-end-labeling (TUNEL)-positive cells in D-gal-treated mice were inhibited by troxerutin, which might be attributed to its antioxidant property by decreasing activities of nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxidase) and levels of reactive oxygen species (ROS). In conclusion, these results suggested that troxerutin could protect the mouse kidney against D-gal-induced injury by improv...Continue Reading

References

May 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·J M McCordI Fridovich
Feb 1, 1984·Biochemical Pharmacology·M Ogata, H Aikoh
Jan 1, 1984·Methods in Enzymology·H Aebi
Jan 16, 1995·FEBS Letters·S ToyokuniH Hiai
Dec 1, 1995·Toxicology Letters·A F SlaterS Orrenius
Feb 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·H J HelbockB N Ames
Mar 10, 2000·European Journal of Pharmacology·S CuzzocreaC Thiemermann
Jan 5, 2002·Physiological Reviews·Wulf Dröge
May 1, 2002·Current Opinion in Nephrology and Hypertension·Ramon Bonegio, Wilfred Lieberthal
Jun 18, 2002·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A ImaedaH Nagase
Sep 14, 2002·The Journal of Dermatological Treatment·M KesslerL Jung
Aug 6, 2003·Free Radical Biology & Medicine·Patty J Lee, Augustine M K Choi
Aug 12, 2004·Journal of Radiation Research·Dharmendra Kumar MauryaCherupally Krishnan Krishnan Nair
Dec 23, 2004·Journal of Radiation Research·Nitin Motilal GandhiCherupally Krishnan K Nair
Feb 11, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jie WuGuangyan Cai
Jun 28, 2005·Neurological Research·Qing ZhangPingping Zuo
Aug 6, 2005·Proceedings of the National Academy of Sciences of the United States of America·Jane TianJames T Handa
Sep 15, 2005·Legal Medicine·Itsuo TokunagaOsamu Kitamura
Oct 11, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Marcus S CookeMark D Evans
Nov 29, 2005·Molecular and Cellular Biochemistry·Dharmendra Kumar MauryaCherupally Krishnan Krishnan Nair
Jan 25, 2006·Chemico-biological Interactions·M ValkoM Mazur
May 11, 2006·International Archives of Occupational and Environmental Health·A Pilger, H W Rüdiger
Jul 1, 2006·World Journal of Gastroenterology : WJG·Zheng-Ming ShiXue-Jiang Wang
Sep 7, 2006·Proceedings of the National Academy of Sciences of the United States of America·Weijing CaiHelen Vlassara
Oct 21, 2006·Biochemical Society Transactions·R DworakowskiA M Shah
Dec 13, 2006·Toxicology·Heloísa D C FrancescatoTerezila M Coimbra
Aug 19, 2007·Life Sciences·Telma de Jesus SoaresTerezila M Coimbra
Nov 21, 2007·Journal of Bioscience and Bioengineering·Masaaki UekiNobuhiro Maekawa
Feb 26, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Xiaolei JinRekha Mehta
Apr 15, 2008·Journal of Occupational Health·Noriyuki YoshiokaKazuyuki Omae
Apr 18, 2008·European Journal of Pharmacology·Agnes W BootsAalt Bast

❮ Previous
Next ❯

Citations

Dec 17, 2011·Toxicology and Applied Pharmacology·Chan-Min LiuYun-Zhi Sun
Jul 27, 2011·Environmental Toxicology and Pharmacology·Jie-Qiong MaYun-Zhi Sun
Mar 27, 2016·Chemico-biological Interactions·Niranjan A PanatSaroj S Ghaskadbi
Jun 19, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Lulu ZhangYuan Yuan
May 5, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Fei YuJun Yang
Dec 3, 2014·Clinics and Research in Hepatology and Gastroenterology·Jie-Qiong MaChan-Min Liu
Oct 18, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Chan-Min LiuYun-Zhi Sun
Feb 12, 2017·Canadian Journal of Physiology and Pharmacology·Mohammad ZamanianMohammad Allahtavakoli
Jun 11, 2014·Food & Function·Enting WangYuan Yuan
Feb 28, 2018·Archives of Physiology and Biochemistry·Parvin BayandorShirin Babri
Sep 21, 2019·Biogerontology·Khairunnuur Fairuz Azman, Rahimah Zakaria
Nov 1, 2013·Molecular and Cellular Biochemistry·Rajagopalan GeethaCarani Venkatraman Anuradha
Apr 15, 2018·Acta chirurgica Belgica·Fereshteh DehnamakiGholamreza Bazmandegan
Sep 27, 2019·Ear, Nose, & Throat Journal·Cong Li, Song Shi
Aug 29, 2021·Molecular Nutrition & Food Research·Jan HomolakMelita Salkovic-Petrisic
Oct 16, 2020·Naunyn-Schmiedeberg's Archives of Pharmacology·Gholamreza BazmandeganMorteza Amirteimoury

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.