Chronic adolescent exposure to Δ-9-tetrahydrocannabinol in COMT mutant mice: impact on psychosis-related and other phenotypes.

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
C M P O'TuathaighJ L Waddington

Abstract

Cannabis use confers a two-fold increase in the risk for psychosis, with adolescent use conferring even greater risk. A high-low activity catechol-O-methyltransferase (COMT) polymorphism may modulate the effects of adolescent Δ-9-tetrahydrocannabinol (THC) exposure on the risk for adult psychosis. Mice with knockout of the COMT gene were treated chronically with THC (4.0 and 8.0 mg/kg over 20 days) during either adolescence (postnatal days (PDs) 32-52) or adulthood (PDs 70-90). The effects of THC exposure were then assessed in adulthood across behavioral phenotypes relevant for psychosis: exploratory activity, spatial working memory (spontaneous and delayed alternation), object recognition memory, social interaction (sociability and social novelty preference), and anxiety (elevated plus maze). Adolescent THC administration induced a larger increase in exploratory activity, greater impairment in spatial working memory, and a stronger anti-anxiety effect in COMT knockouts than in wild types, primarily among males. No such effects of selective adolescent THC administration were evident for other behaviors. Both object recognition memory and social novelty preference were disrupted by either adolescent or adult THC administration, ...Continue Reading

References

Mar 1, 1988·The Journal of Comparative Neurology·A KalsbeekH B Uylings
Jan 1, 1995·Neurotoxicology and Teratology·R C BelueD E Hutchings
May 1, 1994·The British Journal of Psychiatry : the Journal of Mental Science·M J Martinez-ArevaloJ R Varo-Prieto
Aug 1, 1994·Drug and Alcohol Dependence·C R McLaughlinM E Abood
Apr 1, 1994·Archives of General Psychiatry·D H LinszenM E Lenior
Feb 1, 1993·Neuroreport·F Rodríguez de FonsecaJ J Fernández-Ruiz
Nov 21, 1995·Brain Research. Developmental Brain Research·M H TeicherJ C Hostetter
Jun 1, 1997·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·J D JentschR H Roth
Aug 26, 1998·Proceedings of the National Academy of Sciences of the United States of America·J A GogosM Karayiorgou
Mar 17, 2000·Brain Research. Brain Research Reviews·P S Goldman-RakicG V Williams
Mar 20, 2001·Nature Reviews. Neuroscience·M W Brown, J P Aggleton
Jun 8, 2001·Proceedings of the National Academy of Sciences of the United States of America·M F EganD R Weinberger
Aug 8, 2001·The European Journal of Neuroscience·M PistisG L Gessa
Feb 12, 2002·Neuroscience and Biobehavioral Reviews·Robert Lalonde
Nov 20, 2002·The Journal of Pharmacology and Experimental Therapeutics·Marko HuotariPekka T Männistö
Nov 26, 2002·BMJ : British Medical Journal·George C PattonWayne Hall
Nov 26, 2002·BMJ : British Medical Journal·Louise ArseneaultTerrie E Moffitt
Dec 14, 2002·Neuroscience and Biobehavioral Reviews·Martin R Yeomans, Richard W Gray
Apr 30, 2003·Proceedings of the National Academy of Sciences of the United States of America·Venkata S MattayDaniel R Weinberger
Jul 29, 2003·Journal of Applied Toxicology : JAT·Kristiina HaasioPekka T Männistö
Jul 31, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Miriam Schneider, Michael Koch
Oct 24, 2003·Psychopharmacology·Marko HuotariPekka T Männistö
Feb 3, 2004·The British Journal of Psychiatry : the Journal of Mental Science·Louise ArseneaultRobin M Murray
Jun 3, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Deepak Cyril D'SouzaJohn Harrison Krystal
Jun 9, 2004·Neurobiology of Learning and Memory·Rebecca S HammondRobert W Stackman
Sep 24, 2004·Progress in Neurobiology·Jeremy K Seamans, Charles R Yang
Mar 23, 2005·Biological Psychiatry·Deepak Cyril D'SouzaJohn Harrison Krystal
Jun 2, 2005·Pharmacology, Biochemistry, and Behavior·M P ViverosSandra E File
Oct 4, 2005·Biological Psychiatry·Geena Mary V SankoorikalEdward S Brodkin
Feb 16, 2006·Biological Psychiatry·Elizabeth M TunbridgeDaniel R Weinberger
Apr 25, 2006·Pharmacology, Biochemistry, and Behavior·Young May ChaH S Swartzwelder
Jul 21, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·George V Rebec
Aug 29, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Cécile HenquetJim van Os

❮ Previous
Next ❯

Citations

Jul 22, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ruud van WinkelUNKNOWN Genetic Risk and Outcome of Psychosis (GROUP) Investigators
Mar 22, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Aine T BehanDavid R Cotter
Mar 2, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Antonio Verdejo-GarcíaRafael de la Torre
Oct 27, 2010·Pharmacogenetics and Genomics·Anne Emilia Tammimäki, Pekka T Männistö
Oct 1, 2011·Science Translational Medicine·Martien J KasIiris Hovatta
Sep 9, 2011·Future Neurology·Simone B SartoriNicolas Singewald
Jan 30, 2014·Annual Review of Clinical Psychology·Ruud van Winkel, Rebecca Kuepper
Jun 12, 2013·Neurobiology of Disease·Geetha KannanMikhail V Pletnikov
Nov 19, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Colm M P O'TuathaighJohn L Waddington
Aug 7, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·T Rubino, D Parolaro
Jul 12, 2011·Behavioural Brain Research·Andrea T U Schaefers, York Winter
Sep 8, 2015·Biological Psychiatry·Tiziana Rubino, Daniela Parolaro
May 12, 2015·Neuroscience and Biobehavioral Reviews·Alejandro Higuera-MatasEmilio Ambrosio
Mar 13, 2015·Frontiers in Psychiatry·James N Samsom, Albert H C Wong
Nov 15, 2011·The International Journal of Neuropsychopharmacology·Colm M P O'TuathaighJohn L Waddington
Nov 27, 2014·Frontiers in Neuroscience·Justine RenardThérèse M Jay
Apr 10, 2013·Neuroscience and Biobehavioral Reviews·Enoch NgJohn C Roder
Dec 21, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Emma L BurrowsAnthony J Hannan
Dec 12, 2012·Neurobiology of Disease·Atsushi SaitoAtsushi Kamiya
Jul 20, 2011·Journal of Psychopharmacology·Tiziana RubinoDaniela Parolaro
Dec 18, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Emilie I PetitJohn L Waddington
Jan 24, 2015·Neuroscience and Biobehavioral Reviews·Colm M O'Tuathaigh, John L Waddington
Jul 27, 2012·The Australian and New Zealand Journal of Psychiatry·Anand GururajanMaarten van den Buuse
Jun 22, 2017·International Journal of Molecular Sciences·María A AguilarM Carmen Arenas
Sep 19, 2015·PloS One·Ruud van Winkel, UNKNOWN GROUP Investigators
Dec 14, 2012·Expert Review of Clinical Pharmacology·Lieve DesbonnetJohn L Waddington
May 29, 2019·The International Journal of Neuropsychopharmacology·Noboru Hiroi, Takahira Yamauchi
Nov 22, 2019·Irish Journal of Psychological Medicine·V RussellJ L Waddington
Oct 12, 2016·Neural Plasticity·Paula MoranColm O'Tuathaigh
Jan 11, 2020·Frontiers in Pharmacology·Sabrina Rahman Archie, Luca Cucullo
Dec 11, 2020·Schizophrenia Research·Valentine BouetMichel Boulouard
Dec 2, 2017·Progress in Neuro-psychopharmacology & Biological Psychiatry·E CoskerV Laprévote
Apr 4, 2021·International Journal of Molecular Sciences·Solenn PercelayValentine Bouet
May 3, 2011·Neuroscience and Biobehavioral Reviews·Paola CasadioMarta Di Forti

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.