Chronic adrenergic receptor blockade does not prevent hyperinsulinemia-induced hypertension in rats

American Journal of Hypertension
H L KeenJ E Hall

Abstract

Increased adrenergic activity has been suggested to mediate the hypertension associated with hyperinsulinemia. This study tested whether combined alpha1- and beta-adrenergic receptor blockade would prevent insulin-induced hypertension when euglycemia was maintained by continuous intravenous glucose infusion. Sprague-Dawley rats (n = 16) were instrumented with artery and vein catheters and placed in metabolic cages. Propranolol and prazosin (10 mg/kg/day each) were infused continuously intravenously in 9 rats and 7 other rats received vehicle. Mean arterial pressure (MAP) and heart rate (HR) were measured 24 h per day using computerized methods. After a control period, a 7-day intravenous infusion of insulin (1.5 microU/kg/min) was begun and glucose was coadministered intravenously at 23 mg/kg/min to prevent hypoglycemia. The MAP averaged 93 +/- 1 mm Hg in the blockade rats during the control period, which was significantly lower than the 98 +/- 1 mm Hg in the normal rats. During insulin infusion, MAP increased similarly in both groups, with a 10 +/- 2 mm Hg and 11 +/- 1 mm Hg increase in normal and blockade rats, respectively, by day 7. The HR also increased in both groups: from 417 +/- 8 beats/ min to 426 +/- 13 beats/min (P =...Continue Reading

Citations

Mar 11, 1998·Clinical and Experimental Pharmacology & Physiology·M W BrandsH L Keen
Oct 5, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Michael W Brands, M Marlina Manhiani
Mar 31, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Manisha GupteLisa A Cassis
Nov 30, 2006·Clinical and Experimental Hypertension : CHE·Anees Ahmad Banday, Mustafa F Lokhandwala
Feb 8, 2003·Hypertension·Christie R Claxton, Michael W Brands
Aug 10, 2007·American Journal of Physiology. Renal Physiology·Swasti TiwariCarolyn A Ecelbarger
Jan 11, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jay J KuoJohn E Hall
Dec 30, 1998·Journal of Hypertension·T C Fang, W C Huang
Nov 14, 1998·The American Journal of Physiology·Z K KrowickiP J Hornby

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