Chronic alcohol consumption affects gastrointestinal motility and reduces the proportion of neuronal NOS-immunoreactive myenteric neurons in the murine jejunum

The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology
Mária BagyánszkiJean-Pierre Timmermans

Abstract

Alcohol consumption interferes with gastrointestinal transit causing symptoms in alcoholic patients. Nitric oxide (NO), synthesized by neuronal nitric oxide synthase (nNOS) plays an important role in the control of gastrointestinal motility. Our aim was to investigate whether chronic alcohol intake in a murine model induces gastrointestinal motility disturbances and affects the nitrergic myenteric neurons in the stomach and jejunum. Gastric emptying, small intestinal transit and geometric centre were measured in vivo after intragastric gavage of Evans blue. Nitrergic relaxations to electrical field stimulation (EFS) and exogenous NO were recorded in jejunal muscle strips in vitro. The proportion of nNOS-immunopositive myenteric neurons was assessed using PGP9.5 and nNOS immunostaining. After chronic alcohol consumption, gastric emptying and small intestinal transit were delayed compared with control mice, and the nitrergic nerve-mediated relaxations to EFS in the jejunum were decreased, whereas relaxations to exogenous NO did not differ. The proportion of nNOS-immunoreactive neurons did not change in the stomach, whereas in the jejunum the percentage decreased from 33% to 27% (P < 0.001) after chronic alcohol intake. The total ...Continue Reading

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Citations

May 31, 2012·World Journal of Diabetes·Mária Bagyánszki, Nikolett Bódi
Dec 21, 2010·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·H JingC Liu
Apr 8, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M BagyánszkiA B A Kroese
Nov 30, 2011·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Christopher R NaumannCynthia W Ko
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Sep 1, 2016·Oxidative Medicine and Cellular Longevity·Nathalia Carolina Fernandes FagundesRafael Rodrigues Lima
Jul 29, 2016·British Journal of Nursing : BJN·Mohammed Abdullah Al Maqbali
Jan 9, 2013·The American Journal of Gastroenterology·Kerryn W RedingMargaret M Heitkemper
Jun 20, 2017·International Journal of Molecular Medicine·Nian WangJie Chen
May 10, 2020·BMJ Open Gastroenterology·Jean Bosco BangamwaboTimothy D Walker
Apr 27, 2019·International Journal of Molecular Sciences·Nikolett BódiMária Bagyánszki
May 25, 2020·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Zorisadday GonzalezRichard McCallum

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