Chronic alterations in ovine maternal corticosteroid levels influence uterine blood flow and placental and fetal growth

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
E C JensenMaureen Keller-Wood

Abstract

Previous work from this laboratory demonstrated that the elevation of maternal plasma corticosteroid concentrations during pregnancy is important for the support of fetal development. Reducing ovine maternal plasma cortisol concentrations to nonpregnant levels stimulates homeostatic responses that defend fetal blood volume. The present study was designed to test the hypothesis that chronic decreases or increases in maternal plasma cortisol concentration alter uterine and placental blood flow and morphology. Three groups of pregnant ewes and their fetuses were chronically catheterized and studied: ewes infused with cortisol (1 mg.kg(-1).day(-1); high cortisol), ewes adrenalectomized and underreplaced with cortisol (0.5 mg.kg(-1).day(-1); low cortisol), and control ewes. The normal increment in uterine blood flow between 120 and 130 days was eliminated in the low-cortisol ewes; conversely, uterine blood flow was increased in the high-cortisol group compared with the control group. Fetal arterial blood pressure was increased in the high-cortisol group compared with controls, but there was no increase in fetal arterial pressure from 120 to 130 days of gestation in the low-cortisol group. The fetuses of both low-cortisol and high-co...Continue Reading

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Citations

Jun 4, 2011·Reproduction, Fertility, and Development·Ellen C JensenMaureen Keller-Wood
Jan 6, 2011·American Journal of Physiology. Endocrinology and Metabolism·Melissa LingisMaureen Keller-Wood
May 24, 2008·Reproductive Sciences·Katherine Chang, Lubo Zhang
Jun 30, 2006·The Journal of Reproduction and Development·Takehiro NishidaMotohiko Ishida
Mar 15, 2005·Scandinavian Journal of Psychology·Eva Jensen
Dec 31, 2011·Neuroscience and Biobehavioral Reviews·Jian LiBerthold Hocher
Apr 17, 2007·Neurotoxicology and Teratology·Karin S Hougaard, Ase M Hansen
Dec 4, 2013·Hypertension·Carine Gennari-MoserMarkus G Mohaupt
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Feb 27, 2016·F1000Research·Charles E Wood, Maureen Keller-Wood
Dec 14, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jeffrey Schwartz, Janna L Morrison
Jan 10, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Andrew AntolicMaureen Keller-Wood
Dec 15, 2005·Physiological Genomics·Maureen Keller-WoodCharles E Wood
Aug 12, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Seth A ReiniMaureen Keller-Wood
Apr 27, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Feng LiMaureen Keller-Wood
Jun 13, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Maureen Keller-WoodSha Tao
Feb 18, 2020·Prenatal Diagnosis·Eniola Raheem IbirogbaRodrigo Ruano
Oct 19, 2017·Stress : the International Journal on the Biology of Stress·Michelle DreilingFlorian Rakers
Sep 22, 2020·American Journal of Physiology. Endocrinology and Metabolism·Serene JosephMaureen Keller-Wood
Dec 20, 2007·The Journal of Cardiovascular Nursing·Maureen McCormick CovelliHossein N Yarandi
Jan 15, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·E C JensenA J Gunn
Aug 14, 2008·American Journal of Physiology. Endocrinology and Metabolism·Maureen Keller-Wood, Charles E Wood
Jun 21, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Xiaodi FengMaureen Keller-Wood
Nov 3, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Andrew AntolicMaureen Keller-Wood

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