Chronic alterations in the cellular composition of spinal cord white matter following contusion injury

Glia
Lisa J RosenbergJean R Wrathall

Abstract

Spinal cord injury (SCI) involves the loss of neurons and glia due to initial mechanical and secondary biochemical mechanisms. Treatment with the sodium channel blocker tetrodotoxin (TTX) reduces acute white matter pathology and increases both axon density and hindlimb function chronically at 6 weeks after injury. We investigated the cellular composition of residual white matter chronically to determine whether TTX also has a significant effect on the numbers and types of cells present. Rats received an incomplete thoracic contusion injury, in the presence or absence of TTX (0.15 nmole) injected focally, beginning at 15 min prior to injury. Six weeks later, cell density was significantly increased in the residual white matter of the dorsal, lateral, and ventral funiculi, both rostral and caudal to the injury site in both TTX-treated and injury control groups. Oligodendrocyte and astrocyte density was similar to normal but large numbers of cells expressing microglia/macrophage markers were present. Labeling with the progenitor markers nestin and NG2 showed that precursor cell density had also doubled or tripled as compared with uninjured controls. Some of these cells were also labeled for antigens that indicate their possible pr...Continue Reading

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Citations

Dec 23, 2006·Journal of Neurotrauma·Judith M LytleJean R Wrathall
Mar 26, 2009·Frontiers in Neuroendocrinology·Alejandro F De NicolaMichael Schumacher
Sep 28, 2005·Journal of Cellular Biochemistry·Yu-Ping ChangShun-Fen Tzeng
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Oct 3, 2012·Stem Cells International·Solomon O Ugoya, Jian Tu
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May 2, 2019·Cellular and Molecular Life Sciences : CMLS·Oscar SeiraWolfram Tetzlaff
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