Chronic aluminum administration to old rats results in increased levels of brain metal ions and enlarged hippocampal mossy fibers

Annals of the New York Academy of Sciences
Patrizia FattorettiP Zatta

Abstract

The effect of chronic aluminium administration (2 g/L/6 months) was investigated in the central nervous system (CNS) of old rats. The content of Al(3+), Cu(2+), Zn(2+), and Mn(2+) was measured in prosencephalon + mesencephalon, pons-medulla, and cerebellum. The area occupied by the mossy fibers in the hippocampal CA3 zone was also measured. In Al-treated rats the contents of Al(3+), Cu(2+), Zn(2+), and Mn(2+) were significantly increased in prosencephalon + mesencephalon and pons-medulla, while no change was observed in the cerebellum except a Cu(2+) decrease. The area occupied by the mossy fibers in the CA3 field was significantly increased (+32%) in Al-treated rats. Taken together, the present findings document that the aging CNS is particularly susceptible to aluminum toxic effects that may be responsible for a consistent rise in the cell load of oxidative stress. This may contribute, as an aggravating factor, to the development of neurodegenerative events, as observed in Alzheimer disease.

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Citations

Jun 28, 2005·Biochimica Et Biophysica Acta·Christopher J L Silwood, Martin Grootveld
Dec 22, 2007·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Daniel KrewskiVirginie Rondeau
Sep 15, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jason R Cannon, J Timothy Greenamyre
Oct 1, 2005·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Yasushi NakagawaToru Iwaki
Jun 16, 2009·Nanomedicine : Nanotechnology, Biology, and Medicine·Xiao-Bo LiShun-Qing Xu
Feb 17, 2007·Neurotoxicology·Bettina PlattAthanasios Salifoglou
Oct 25, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·S MayaDivakar Goli
Nov 9, 2017·Frontiers in Molecular Neuroscience·Yong LiHong Jiang
Sep 6, 2020·Molecular Neurobiology·Md Tanvir KabirMohamed M Abdel-Daim
Mar 29, 2013·The Journal of Toxicological Sciences·Lifeng ZhangYuan Cai
Jul 13, 2019·Nutrients·Francisco José Sánchez-MunizMaría José González-Muñoz

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