Chronic AMD3100 antagonism of SDF-1alpha-CXCR4 exacerbates cardiac dysfunction and remodeling after myocardial infarction.

Journal of Molecular and Cellular Cardiology
Shujing DaiGregg Rokosh

Abstract

The role of the SDF-1alpha-CXCR4 axis in response to myocardial infarction is unknown. We addressed it using the CXCR4 antagonist, AMD3100, to block SDF-1alpha interaction with CXCR4 after chronic coronary artery ligation. Chronic AMD3100 treatment decreased ejection fraction and fractional shortening in mice 20days after myocardial infarction compared with vehicle-treated mice (echocardiography). Morphometric analysis showed hearts of AMD3100-treated infarcted mice to have expanded scar, to be hypertrophic (confirmed by myocyte cross-section area) and dilated, with increased LV end systolic and end diastolic dimensions, and to have decreased scar collagen content; p-AKT levels were attenuated and this was accompanied by increased apoptosis. Despite increased injury, c-kit(pos) cardiac progenitor cells (CPCs) were increased in the risk region of AMD3100-treated infarcted mice; CPCs were CD34(neg)/CD45(neg) with the majority undergoing symmetric cell division. c-kit(pos)/MHC(pos) CPCs also increased in the risk region of the AMD3100-treated infarcted group. In this group, GSK-3beta signaling was attenuated compared to vehicle-treated, possibly accounting for increased proliferation and increased cardiac committed MHC(pos) CPCs. ...Continue Reading

References

Apr 17, 1997·The New England Journal of Medicine·G OlivettiP Anversa
Jan 14, 1998·Nature Medicine·G A DonzellaJ P Moore
Jan 5, 2002·The Journal of Biological Chemistry·Ying LiLaurence A Lasky
Jan 22, 2002·Nature Cell Biology·Eiichi OkumuraTakeo Kishimoto
Dec 10, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kent W ChristophersonHal E Broxmeyer
Sep 25, 2003·Cell·Antonio P BeltramiPiero Anversa
Jul 6, 2004·Nature Medicine·Daniel J CeradiniGeoffrey C Gurtner
Sep 2, 2004·Journal of Molecular Histology·Magda KuciaMariusz Z Ratajczak
Apr 20, 2005·The Journal of Experimental Medicine·Hal E BroxmeyerEdward F Srour
Aug 3, 2005·The Journal of Clinical Investigation·Ichiro ShiojimaKenneth Walsh
Aug 10, 2005·Seminars in Cell & Developmental Biology·Dan LuoThomas A Rando
Mar 25, 2006·Circulation Research·Buddhadeb DawnRoberto Bolli
Oct 3, 2006·Journal of Molecular and Cellular Cardiology·Robert T PyoAlison D Schecter
May 24, 2007·Pflügers Archiv : European journal of physiology·Cindy ProulxAngelino Calderone
Apr 2, 2008·The Journal of Experimental Medicine·Yuchun NieYong-Rui Zou
Apr 23, 2008·Circulation·Ankur SaxenaDeepak Srivastava
Aug 20, 2008·Molecular and Cellular Biology·Michelle D LarreaJoyce M Slingerland
Oct 3, 2008·The Journal of Clinical Investigation·Risto KerkelaGordon S Huggins
Nov 29, 2008·Circulation Research·Andreas SkyschallyGerd Heusch
Dec 25, 2008·Proceedings of the National Academy of Sciences of the United States of America·Takahisa MatsudaJunichi Sadoshima

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Citations

Feb 20, 2014·Stem Cells and Development·Miriam BobadillaAna Pérez-Ruiz
Feb 25, 2011·Cardiovascular Research·Jun-Ming TangShi-You Chen
Jun 21, 2011·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Britta BlumenthalMatthias Siepe
Aug 30, 2013·The International Journal of Neuroscience·Weifeng MaoGuohua Jin
Jun 27, 2014·Frontiers in Physiology·Yvonne DöringHeidi Noels
Apr 5, 2017·Journal of Cellular and Molecular Medicine·Xiaoqing YanYi Tan
Feb 18, 2017·Journal of Cellular and Molecular Medicine·Dezhi ChenAixi Yu
May 19, 2012·Circulation Research·Steven R HouserUNKNOWN American Heart Association Council on Basic Cardiovascular Sciences, Council on Clinical Cardiology, and Council on Function
Aug 24, 2010·Journal of Cardiovascular Pharmacology·Thomas J LaRoccaSima T Tarzami
Oct 22, 2016·Molecular and Cellular Biochemistry·Vikrant RaiDevendra K Agrawal
Mar 13, 2015·Expert Review of Clinical Immunology·Andrew A Jarrah, Sima T Tarzami
Dec 7, 2013·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Rebecca J SteagallKrishna Singh
Aug 29, 2014·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Yedidya SaimanMeena B Bansal
Sep 16, 2015·Stem Cells Translational Medicine·Yuri M KlyachkinAhmed Abdel-Latif
Jul 18, 2020·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Mathias Johannes ZacherlBruno C Huber
May 18, 2020·Journal of Cardiovascular Translational Research·Bijun Chen, Nikolaos G Frangogiannis
Aug 3, 2017·Medicinal Research Reviews·Lun Kelvin TsouKak-Shan Shia
Jan 30, 2018·The American Journal of Pathology·David M HabielCory M Hogaboam
Sep 9, 2021·Annals of Medicine·Hussam A S MuradThamer M A Alqurashi

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