Chronic amphetamine treatment enhances corticotropin-releasing factor-induced serotonin release in the amygdala.

European Journal of Pharmacology
J L SchollGina Forster

Abstract

Amphetamine use is associated with dysphoric states, including heightened anxiety, that emerge within 24h of withdrawal from the drug. Corticotropin-releasing factor increases serotonin release in the central nucleus of the amygdala, and this neurochemical circuitry may play a role in mediating fear and anxiety states. We have previously shown that chronic amphetamine treatment increases corticotropin-releasing factor receptor type-2 levels in the serotonergic dorsal raphe nucleus of the rat. Therefore, we hypothesized that chronic amphetamine treatment would enhance the amygdalar serotonergic response to corticotropin-releasing factor infused into the dorsal raphe nucleus. Male rats were injected once-daily with d-amphetamine (2.5mg/kg i.p., or saline) for two weeks. Serotonin release within the central nucleus of the amygdala in response to intra-raphe infusion of corticotropin-releasing factor (100 ng) was measured 24h after the last treatment in urethane-anesthetized (1.8 mg/kg, i.p.) rats using in vivo microdialysis. Rats pretreated with amphetamine showed significantly enhanced serotonin release in the central nucleus of the amygdala in response to corticotropin-releasing factor infusion when compared to saline pretreated...Continue Reading

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Citations

Mar 16, 2013·Histochemistry and Cell Biology·Esther AsanKlaus-Peter Lesch
Jun 10, 2014·Pharmacological Reports : PR·Grażyna BiałaBarbara Budzyńska
Dec 27, 2011·Neuropharmacology·Caroline E McCardle, Sarah E Gartside
Nov 1, 2011·Neuroscience and Biobehavioral Reviews·Thibault RenoirLaurence Lanfumey
Sep 11, 2014·Neuroscience Research·Emily D ReinboldGina L Forster
Apr 10, 2018·Experimental & Molecular Medicine·Olga BabaevDilja Krueger-Burg
Nov 23, 2017·Frontiers in Neuroscience·Nathan VinzantGina L Forster

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