PMID: 2498949Jan 1, 1989Paper

Chronic and acute tolerance to the heart rate effects of nicotine

Psychopharmacology
K A PerkinsR G Jacob

Abstract

Tolerance to the effects of nicotine reflects physiological adaptation and may be related to the development and persistence of smoking behavior. However, little is known about tolerance to nicotine in humans, in part due to methodological difficulties. This study examined chronic and acute tolerance to nicotine's effect on heart rate (HR) using a measured-dose nasal spray nicotine procedure. Eight "Light" smokers (less than 20 cigarettes per day) and ten "Heavy" smokers (greater than or equal to 20 per day) participated in two sessions on separate days in which they received four administrations (1 every 20 min) of a high nicotine dose (15 micrograms per kg body weight, equivalent to a typical cigarette) or a low nicotine dose (7.5 micrograms/kg) while HR was monitored during the 5 min following each administration. Compared with Light smokers, Heavy smokers had significantly smaller HR responses to the high dose, indicating greater chronic tolerance, but there was no difference between groups in response to the low dose. Acute tolerance to HR response across the four 5-min periods was not observed with either dose. However, subsequent examination of HR response in the first 2 min following each dose administration did suggest...Continue Reading

References

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Jan 1, 1986·Psychopharmacology·K A PerkinsR Stiller
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Citations

Mar 1, 1995·Behavior Genetics·K A Perkins
Jan 1, 1992·Psychopharmacology·K D WardR E Bliss
Mar 1, 1995·Psychopharmacology·K A PerkinsA Scierka
Jan 1, 1992·Psychopharmacology·G SutherlandO Ferno
Jan 1, 1992·Psychopharmacology·S ShiffmanG O'Brien
Sep 1, 1990·Pharmacology, Biochemistry, and Behavior·K A PerkinsR G Jacob
May 1, 1991·Pharmacology, Biochemistry, and Behavior·L H EpsteinJ A Smith
Jun 1, 1993·Pharmacology, Biochemistry, and Behavior·K A PerkinsR G Jacob
Jan 1, 1994·Pharmacology, Biochemistry, and Behavior·A JacoberK Bättig
May 1, 1992·Progress in Neuro-psychopharmacology & Biological Psychiatry·H Frances, C Monier
May 18, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jack H MendelsonNancy K Mello
Oct 1, 1990·British Journal of Addiction·C S PomerleauE M Morrell
May 1, 1990·Clinical and Experimental Pharmacology & Physiology·K A PerkinsR G Jacob
Oct 20, 2009·Hormones and Behavior·Nancy K Mello
Jan 1, 1992·Journal of Substance Abuse·K A PerkinsR L Stiller
Apr 6, 1989·The New England Journal of Medicine·K A PerkinsR G Jacob
Apr 30, 1999·Journal of Psychopharmacology·V Della CasaJ Feldon
Jan 24, 2020·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Aleksandra HerbecRobert West

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