Chronic and intermittent administration of systemic nitroglycerin in the rat induces an increase in the gene expression of CGRP in central areas: potential contribution to pain processing

The Journal of Headache and Pain
Rosaria GrecoCristina Tassorelli

Abstract

Calcitonin gene related peptide (CGRP) is a key neuropeptide involved in the activation of the trigeminovascular system and it is likely related to migraine chronification. Here, we investigated the role of CGRP in an animal model that mimics the chronic migraine condition via repeated and intermittent nitroglycerin (NTG) administration. We also evaluated the modulatory effect of topiramate on this experimental paradigm. Male Sprague-Dawley rats were injected with NTG (5 mg/kg, i.p.) or vehicle, every 2 days over a 9-day period (5 total injections). A group of animals was injected with topiramate (30 mg/kg, i.p.) or saline every day for 9 days. Twenty-four hours after the last administration of NTG or vehicle, animals underwent tail flick test and orofacial Von Frey test. Rats were subsequently sacrificed to evaluate c-Fos and CGRP gene expression in medulla-pons region, cervical spinal cord and trigeminal ganglia. NTG administration induced spinal hyperalgesia and orofacial allodynia, together with a significant increase in the expression of CGRP and c-Fos genes in trigeminal ganglia and central areas. Topiramate treatment prevented NTG-induced changes by reversing NTG-induced hyperalgesia and allodynia, and inhibiting CGRP an...Continue Reading

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Citations

Jul 11, 2019·Cephalalgia : an International Journal of Headache·Sarah L ChristensenGordon Munro
Aug 30, 2019·The Journal of Headache and Pain·Andrea M HarriottPhilip R Holland
Jun 30, 2019·Disease Models & Mechanisms·Lucie ValekIrmgard Tegeder
Aug 5, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Chung-Chih LiaoChing-Liang Hsieh
Oct 29, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Hung-Ruei TzengLih-Chu Chiou
Oct 26, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Rosaria GrecoCristina Tassorelli
Jan 16, 2021·Journal of Molecular Neuroscience : MN·Kaveh EbahimzadehSoudeh Ghafouri-Fard
May 18, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Shiyu MaLan Shen

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GraphPad Prism
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