Chronic and Occult Hepatitis B Virus Infection in Pregnant Women in Botswana

Genes
Tshepiso MbangiwaSimani Gaseitsiwe

Abstract

The hepatitis B virus (HBV) is a global problem; however, the burden of HBV infection in pregnant women in Botswana is unknown. We sought to determine the prevalence of chronic and occult HBV infection in human immunodeficiency virus (HIV)-infected and -uninfected pregnant women in Botswana. Samples from 752 pregnant women were tested for hepatitis B surface antigen (HBsAg), and HBsAg-positive samples were tested for hepatitis B e antigen (HBeAg) and HBV DNA load. Samples that were HBsAg negative were screened for occult HBV infection by determining the HBV DNA load. HBV genotypes were determined based on a 415-base-pair fragment of the surface gene. Among the 752 women tested during pregnancy or early postpartum, 16 (2.1%) (95% confidence interval (CI): 2.0⁻2.2) were HBsAg-positive. The prevalence of chronic HBV infection was higher (3.1%) among HIV-infected (95% CI: 3.0⁻3.2) compared with HIV-uninfected women (1.1%) (95% CI: 1.07⁻1.1, p = 0.057). Among the 622 HBsAg-negative women, the prevalence of occult HBV infection was 6.6% (95% CI: 6.5⁻6.7). Three of thirteen HBsAg-positive participants were HBeAg-positive, and all were HIV-negative. Of the 11 maternal samples successfully genotyped, five (45.5%) were genotype D3, five ...Continue Reading

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Citations

Nov 2, 2018·Virus Genes·Wonderful T ChogaSimani Gaseitsiwe
Oct 1, 2020·Memórias do Instituto Oswaldo Cruz·Nédio MabundaIlesh Jani
Nov 2, 2021·Journal of Applied Microbiology·Nathália Alves Araujo de Almeida, Vanessa Salete de Paula

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Datasets Mentioned

BETA
MG977701

Methods Mentioned

BETA
Genotyping
PCR

Software Mentioned

Bayesian evolutionary analysis by sampling trees ( BEAST )
Tracer
Tree Annotator
Clustal X
Sequencher
FigTree
STATA

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