Chronic and Refractory Pain: A Systematic Review of Pharmacologic Management in Oncology


Clinical Journal of Oncology Nursing
Jeannine M BrantLinda H Eaton

Abstract

Chronic and refractory cancer pain are significant issues and can increase patient suffering and compromise quality of life. A variety of evidence-based pharmacologic strategies can be used routinely to control cancer pain. 
. The purpose of this study is to conduct a systematic review of the pharmacologic evidence in the management of chronic and refractory cancer pain. 
. The Oncology Nursing Society's Putting Evidence Into Practice pain team conducted a search of 184 systematic reviews, meta-analyses, research studies, and guidelines and classified the evidence into weight-of-evidence categories. 
. Opioids are the mainstay of cancer pain management, but evidence supports the use of coanalgesics and adjuvants to improve overall pain management. Complementary pharmacologic strategies, such as caffeine and herbal preparations, are under investigation, but additional research is needed to recommend these modalities.
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Citations

May 16, 2019·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ellen M Lavoie Smith
Aug 28, 2020·Frontiers in Psychology·Ana Carolina Pinheiro CamposRaquel Chacon Ruiz Martinez
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Jul 3, 2018·Asia-Pacific Journal of Oncology Nursing·Jeannine M Brant
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Jan 4, 2022·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Jia-Hua WangChieh-Yu Liu

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