Chronic ANG II infusion increases NO generation by rat descending vasa recta

American Journal of Physiology. Heart and Circulatory Physiology
Zhong ZhangThomas L Pallone

Abstract

We tested whether chronic ANG II infusion into rats affects descending vasa recta (DVR) contractility, synthesis of superoxide, or synthesis of nitric oxide (NO). Rats were infused with ANG II at 250 ng.kg(-1).min(-1) for 11-13 days. DVR were loaded with dihydroethidium (DHE) to measure superoxide and 3-amino-4-aminomethyl-2',7'-difluorofluorescein (DAFFM) to measure NO. Acute constriction of DVR by ANG II (0.1, 1, and 10 nM) was diminished, and NO generation rate was raised by chronic ANG II infusion. DHE oxidation by DVR from ANG II-infused rats was similar to controls and was significantly higher when NO synthesis was prevented with N(omega)-nitro-L-arginine methyl ester (L-NAME). The superoxide dismutase mimetic Tempol (1 mM) increased NO generation compared with controls. The increased synthesis of NO by chronic ANG II-treated vessels persisted in the presence of Tempol. DVR endothelial cytoplasmic Ca(2+) response to ACh was diminished by chronic ANG II treatment, but the capacity of ACh to increase NO generation was unaltered. We conclude that DVR generation of superoxide is not affected by chronic ANG II exposure but that basal NO synthesis is increased. DVR superoxide is unlikely to be an important mediator of chronic A...Continue Reading

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Citations

Apr 21, 2005·Kidney International·Kensuke AsabaChristopher S Wilcox
Dec 30, 2008·Pharmacological Reviews·Christopher S Wilcox, Adam Pearlman
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May 11, 2021·American Journal of Physiology. Renal Physiology·Matthew A SparksThomas M Coffman
Jul 17, 2021·Journal of Cardiovascular Pharmacology·Mikael EkholmThomas Kahan

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